hs-CRP baseline and after 8 weeks of BPC — chart inside
16 posts
Did a little self-experiment because I was curious if BPC-157 actually moves inflammatory markers systemically or only locally.
Protocol: BPC-157 250mcg subQ peri-umbilical, 2x/day, 56 days. No other changes — same training, same diet, no injuries.
hs-CRP readings (Quest, all fasted AM, Tuesdays):
- Day 0: 1.8 mg/L
- Day 14: 1.4
- Day 28: 1.1
- Day 42: 0.9
- Day 56: 0.7
- Day 70 (2 wks off): 1.1
- Day 84 (4 wks off): 1.6
So a 61% drop over 8 weeks, and a clear rebound 2-4 weeks after stopping. That's a cleaner dose-response than I expected.
Caveats upfront: single person, CRP is famously noisy, no control period. But the monotonic decline + rebound is suggestive.
Anyone done a similar tracking?
16 Replies
16 posts
Fully agreed. I flagged the noise issue because it's real. If I were doing this again I'd do 2 draws at each timepoint 3-5 days apart to get a tighter signal. Budget said no.
122 posts
Going to be 'that guy' — hs-CRP CV is 30-50% within person depending on assay and baseline level. Your day-0 of 1.8 vs day-56 of 0.7 is inside CV for a single datapoint pair. What saves your analysis is the MONOTONIC trend and the rebound. Those two things together are a lot more convincing than any single number.
28 posts
My hs-CRP dropped 2.1 -> 1.0 over a similar BPC/TB combo cycle (8 weeks, 300mcg BPC bid + TB 2mg/wk). Rebound after stopping also. So you're not alone.
52 posts
Interesting. I'd always assumed BPC's anti-inflammatory effect was primarily local (injection site / gut). A systemic hs-CRP drop changes that model.
- BPC-157 · 250 mcg · 2x/day local · sub-Q
- TB-500 · 2 mg · weekly · sub-Q
16 posts
I pulled ferritin at day 0 and day 56. 118 -> 94 ng/mL. Directionally consistent with inflammation coming down, but ferritin is also iron status so it's muddy.
117 posts
The existing literature on BPC-157 is almost entirely rodent + in vitro. There's no published human hs-CRP data I'm aware of. So this kind of community tracking is genuinely the best we have.
34 posts
Could also just be a natural inflammatory event (minor cold, overtraining, bad sleep week) pushing day 70+ readings up. Would want to see multiple cycles/withdrawals to be confident the rebound is real.
16 posts
Fair. I logged training load and sleep — neither was anomalous during the rebound window. But you're right that n=1 with one cycle isn't enough to claim rebound as a real effect.
51 posts
The rebound is the single most interesting piece of this dataset. If it were all placebo or regression to mean, you wouldn't get a reliable bounce-back after withdrawal.
43 posts
Nice work. Anyone planning to repeat this design with BPC alone vs TB alone vs combo would settle a lot of debates.
- Tesamorelin · 1 mg · daily AM · sub-Q
212 posts
I've done TB-500 solo over 10 weeks, hs-CRP went 2.4 -> 1.3. So independently the thymosin-beta arm seems to do something similar. Doesn't isolate either but adds a datapoint.
- CJC-1295 no DAC · 100 mcg · pre-bed · sub-Q
- Ipamorelin · 200 mcg · pre-bed · sub-Q
- BPC-157 · 500 mcg · 2x/day · sub-Q
16 posts
Flattered but overstated. I'd love for someone to do this with n=5-10 and a real washout.
71 posts
Not to harp but I really do think this is the most informative BPC hs-CRP dataset on the English internet right now, noise and all.
20 posts
The rebound after stopping is what got me. Like that's the part that actually convinces me something happened, cause if it was just noise or placebo you wouldn't see that clean of a snapback. Question though, did you notice any sides at 250mcg 2x daily or was it totally clean? Been thinking about running it but mostly for some tendon stuff and don't wanna mess with systemic inflammation if I'm already dealing with minor GI stuff.