hs-CRP baseline and after 8 weeks of BPC — chart inside
10 posts
Did a little self-experiment because I was curious if BPC-157 actually moves inflammatory markers systemically or only locally.
Protocol: BPC-157 250mcg subQ peri-umbilical, 2x/day, 56 days. No other changes — same training, same diet, no injuries.
hs-CRP readings (Quest, all fasted AM, Tuesdays):
- Day 0: 1.8 mg/L
- Day 14: 1.4
- Day 28: 1.1
- Day 42: 0.9
- Day 56: 0.7
- Day 70 (2 wks off): 1.1
- Day 84 (4 wks off): 1.6
So a 61% drop over 8 weeks, and a clear rebound 2-4 weeks after stopping. That's a cleaner dose-response than I expected.
Caveats upfront: single person, CRP is famously noisy, no control period. But the monotonic decline + rebound is suggestive.
Anyone done a similar tracking?
15 Replies
10 posts
Fully agreed. I flagged the noise issue because it's real. If I were doing this again I'd do 2 draws at each timepoint 3-5 days apart to get a tighter signal. Budget said no.
119 posts
Going to be 'that guy' — hs-CRP CV is 30-50% within person depending on assay and baseline level. Your day-0 of 1.8 vs day-56 of 0.7 is inside CV for a single datapoint pair. What saves your analysis is the MONOTONIC trend and the rebound. Those two things together are a lot more convincing than any single number.
26 posts
My hs-CRP dropped 2.1 -> 1.0 over a similar BPC/TB combo cycle (8 weeks, 300mcg BPC bid + TB 2mg/wk). Rebound after stopping also. So you're not alone.
50 posts
Interesting. I'd always assumed BPC's anti-inflammatory effect was primarily local (injection site / gut). A systemic hs-CRP drop changes that model.
- BPC-157 · 250 mcg · 2x/day local · sub-Q
- TB-500 · 2 mg · weekly · sub-Q
10 posts
I pulled ferritin at day 0 and day 56. 118 -> 94 ng/mL. Directionally consistent with inflammation coming down, but ferritin is also iron status so it's muddy.
115 posts
The existing literature on BPC-157 is almost entirely rodent + in vitro. There's no published human hs-CRP data I'm aware of. So this kind of community tracking is genuinely the best we have.
34 posts
Could also just be a natural inflammatory event (minor cold, overtraining, bad sleep week) pushing day 70+ readings up. Would want to see multiple cycles/withdrawals to be confident the rebound is real.
10 posts
Fair. I logged training load and sleep — neither was anomalous during the rebound window. But you're right that n=1 with one cycle isn't enough to claim rebound as a real effect.
50 posts
The rebound is the single most interesting piece of this dataset. If it were all placebo or regression to mean, you wouldn't get a reliable bounce-back after withdrawal.
36 posts
Nice work. Anyone planning to repeat this design with BPC alone vs TB alone vs combo would settle a lot of debates.
- Tesamorelin · 1 mg · daily AM · sub-Q
205 posts
I've done TB-500 solo over 10 weeks, hs-CRP went 2.4 -> 1.3. So independently the thymosin-beta arm seems to do something similar. Doesn't isolate either but adds a datapoint.
- CJC-1295 no DAC · 100 mcg · pre-bed · sub-Q
- Ipamorelin · 200 mcg · pre-bed · sub-Q
- BPC-157 · 500 mcg · 2x/day · sub-Q
10 posts
Flattered but overstated. I'd love for someone to do this with n=5-10 and a real washout.
71 posts
Not to harp but I really do think this is the most informative BPC hs-CRP dataset on the English internet right now, noise and all.