HbA1c ticked up mid-cycle on BPC-157?? (probably nothing, still)
33 posts
8 weeks into BPC-157 (250mcg bid, subQ). Pulled a routine CMP + a1c because I do quarterly labs.
- a1c baseline: 5.1%
- a1c week 8: 5.4%
That's inside the assay's test-retest window, I know. But BPC shouldn't do ANYTHING to glucose. I'm not changing diet. Not stressed. Same training.
Fasting glucose:
- Baseline: 84
- Week 8: 89
Also within noise. But the combination of both trending up on a peptide that shouldn't touch glucose is what's nagging at me.
Is this just test-retest, or have others seen BPC do something to glucose?
9 Replies
33 posts
119 posts
a1c assay CV is ~3%, so the SE on a 5.1 reading is ~0.15. A shift to 5.4 is within 2 SD. You've got nothing here, statistically speaking. Combined with a 5-point fasting glucose move (CV ~4-6%) — also within noise.
I'd retest at week 12 before reading anything into it.
39 posts
Summer/winter effect on a1c is a thing too (people tend to run a touch higher in winter). What months did you draw?
33 posts
27 posts
Diet journal 100% honest? Holiday-season-adjacent snacking creep is the #1 cause of 'mystery a1c drift' in self-trackers and it's really easy to miss 100-200 kcal/day of carbs sneaking in.
- Sermorelin · 300 mcg · pre-bed · sub-Q
- Ipamorelin · 200 mcg · pre-bed · sub-Q
33 posts
10 posts
Also worth noting: BPC is studied for GI stuff and there's some evidence it shifts the microbiome. Microbiome changes -> SCFA changes -> subtle glucose effects. None of this is big enough to move a1c 0.3 points but it's not literally zero mechanism either.
50 posts
Short answer: noise + probably the snack thing. Keep watching, report back at 12 weeks.