Liver enzymes during a long TB-500 cycle

There's your answer. Leg day within 72h will puff ALT and AST via muscle leak (CK too). Not liver. If you want clean LFTs, take 96+ hours off training before the draw.

ALT 24 -> 32 is about 33% which sounds big but is inside within-person CV for ALT (~15-25%) plus the small n. Alone I wouldn't read anything into it. Also, ALT is sensitive to RECENT training — if you trained hard in the 72h before the draw it'll be 10-20% higher just from that.

Trained legs about 48h before the week-8 draw. So that's a confound.

Also pull CK alongside LFTs next time. If CK is elevated, the ALT bump is muscle not liver. Clean way to disambiguate.

I've done 2 long TB cycles (12 and 14 weeks) with LFTs pulled, rest-adjusted, and neither showed any real liver signal. Anecdotal consensus seems to be TB is not hepatotoxic at these doses.

Can confirm — 10 weeks TB, LFTs stone cold flat.

Yeah the leg training 48h prior pretty much kills the signal there. ALT bounces around from literally anything, heavy training, dehydration, even sleep. Honestly if your whole panel stayed in range and you're not jaundiced or anything, TB is prolly clean. That compound gets a lot of hype about being harsh but I've never seen actual evidence of it trashing liver values. Grab that CK next cycle if you wanna be thorough but you're prolly fine.