Prolactin bump on hexarelin — anyone else?
205 posts
I know this is a known side effect but curious about the real-world magnitude.
Hexarelin 100mcg 2x/day for 4 weeks (yes I know that's a short window, the prolactin is part of why).
- Prolactin baseline: 9.1 ng/mL (ref 4-15)
- Prolactin week 4: 22.4 ng/mL (!)
Above the reference range. No symptoms — no galactorrhea, libido fine, no headaches. But 22.4 is a real number.
Is this just hexarelin doing what hexarelin does, or should I be using a cabergoline-style mitigation next time?
- CJC-1295 no DAC · 100 mcg · pre-bed · sub-Q
- Ipamorelin · 200 mcg · pre-bed · sub-Q
- BPC-157 · 500 mcg · 2x/day · sub-Q
7 Replies
94 posts
I switched from hexarelin to ipa specifically because of this. My prolactin on hex was 27 at 6 weeks, symptom-free but annoying. On ipa 300mcg bid my prolactin was 11 at 8 weeks. Night and day.
- CJC-1295 no DAC · 100 mcg · pre-bed · sub-Q
- Ipamorelin · 200 mcg · pre-bed · sub-Q
- BPC-157 · 250 mcg · 2x/day · sub-Q
46 posts
This is consistent with published hexarelin data — it's the 'dirty' GHRP and hits prolactin/cortisol harder than ipa or ghrp-2. 22.4 is elevated but not wildly so. If you're going to run hexarelin more than 4-6 weeks, cabergoline 0.25mg 2x/week is the usual mitigation.
Or just swap to ipa/ghrp-2 if the prolactin bothers you.
205 posts
Both draws ~8am fasted, no training within 12h. So probably real.
- CJC-1295 no DAC · 100 mcg · pre-bed · sub-Q
- Ipamorelin · 200 mcg · pre-bed · sub-Q
- BPC-157 · 500 mcg · 2x/day · sub-Q
27 posts
Draw timing matters a LOT for prolactin — within ~30 min post-workout it can be 2-3x baseline. Stress, sleep issues, nipple stim the night before. Need to standardize draw conditions.
- Sermorelin · 300 mcg · pre-bed · sub-Q
- Ipamorelin · 200 mcg · pre-bed · sub-Q
12 posts
If you're symptom-free and only running 4-6 weeks hex, honestly I'd just ride it out. Cabergoline has its own issues and adding a dopamine agonist to solve a minor asymptomatic elevation is overkill.
- IGF-1 LR3 · 30 mcg · post-workout · sub-Q
- CJC-1295 no DAC · 100 mcg · pre-bed · sub-Q
- Ipamorelin · 200 mcg · pre-bed · sub-Q
- MGF (PEG) · 200 mcg · post-workout · sub-Q
205 posts
Fair. Probably going to just run hex in short 4-week blocks and retest later.
- CJC-1295 no DAC · 100 mcg · pre-bed · sub-Q
- Ipamorelin · 200 mcg · pre-bed · sub-Q
- BPC-157 · 500 mcg · 2x/day · sub-Q