Insulin and glucose on GH secretagogue stack (fasted AM values)
44 posts
Tracking weekly fasting glucose + insulin on a CJC-NoDAC/Ipa/tesa stack (100mcg/200mcg/1mg). 10 weeks in. Same meter (Contour Next), same lab for insulin (Quest), draws Tuesday AM fasted 12h, same restaurant for coffee the day before (kidding).
Glucose (mg/dL, fingerstick mean of 3):
- Wk 0: 84
- Wk 2: 86
- Wk 4: 89
- Wk 6: 91
- Wk 8: 93
- Wk 10: 92
Insulin (mIU/L, lab):
- Wk 0: 5.8
- Wk 4: 7.1
- Wk 8: 8.9
- Wk 10: 9.4
HOMA-IR: 1.20 -> 1.47 -> 2.04 -> 2.14.
That's not catastrophic but it's the 'GH stack insulin creep' I keep reading about. How much of this do I eat before cutting a dose?
8 Replies
94 posts
Agreed with above. My additional take: add berberine 500mg tid if diet is dialed. Cheap insurance, real effect on fasting insulin (~15-20% drop in most responders).
- CJC-1295 no DAC · 100 mcg · pre-bed · sub-Q
- Ipamorelin · 200 mcg · pre-bed · sub-Q
- BPC-157 · 250 mcg · 2x/day · sub-Q
71 posts
My heuristic: HOMA-IR < 1.5 = fine, 1.5-2.0 = monitor, 2.0-2.5 = pull back one lever (drop dose, cut days, or swap tesa out), >2.5 = hard stop on stack and reassess. You're at the 'pull back one lever' threshold.
Easiest lever here is probably cutting tesa to 1mg 5x/wk from 1mg daily, or dropping CJC to 4x/wk.
- BPC-157 · 500 mcg · 2x/day · sub-Q
- GHK-Cu · 2 mg · nightly topical · topical
39 posts
Your glucose trend looks close to maxed-out at 92-93. Likely to stabilize. Insulin is the one you want to watch — it's still climbing.
27 posts
Also — carb timing. If you're eating most carbs in the evening the fasting insulin takes longer to drop overnight. Shifting carbs earlier in the day can reduce fasting insulin 10-20% independent of drug changes.
- Sermorelin · 300 mcg · pre-bed · sub-Q
- Ipamorelin · 200 mcg · pre-bed · sub-Q
31 posts
Are you doing AM dosing? Some people see meaningfully less insulin creep shifting their GH secretagogues to post-workout + bedtime only, skipping the AM pulse.