Fasting insulin and HOMA-IR on CJC/Ipa
27 posts
4 months of CJC-NoDAC 100mcg + Ipa 300mcg, 5x/week. Tracking fasting insulin monthly.
- Month 0: insulin 4.8, glucose 86, HOMA-IR 1.02
- Month 1: insulin 5.2, glucose 88, HOMA-IR 1.13
- Month 2: insulin 6.1, glucose 90, HOMA-IR 1.36
- Month 3: insulin 7.4, glucose 92, HOMA-IR 1.68
- Month 4: insulin 7.8, glucose 93, HOMA-IR 1.79
Looks like it's plateauing around HOMA-IR 1.8. IGF-1 went 187 -> 269 which I'm happy with.
Question: do I ride it out another 2 months (it seems to be stabilizing) or cycle off? No HbA1c yet — pulling it next week.
- Sermorelin · 300 mcg · pre-bed · sub-Q
- Ipamorelin · 200 mcg · pre-bed · sub-Q
7 Replies
94 posts
Same shape on my data last year. Insulin plateaued at ~8, HOMA-IR ~1.85, stayed there for 3 more months. Cycled off for 6 weeks, insulin dropped back to 5.1.
The plateau is not a slow-motion metabolic breakdown, it's the new homeostasis.
- CJC-1295 no DAC · 100 mcg · pre-bed · sub-Q
- Ipamorelin · 200 mcg · pre-bed · sub-Q
- BPC-157 · 250 mcg · 2x/day · sub-Q
46 posts
The plateau is real — fasting insulin tends to hit a new equilibrium 3-4 months into a GHRP stack and stabilize unless you're pushing the dose. If HbA1c stays under 5.5 I'd ride it another 2 months.
If a1c crosses 5.6 I'd cycle off.
33 posts
a1c is really the deciding vote. Get that reading and retest again at month 6. If it's stable under 5.5 you're fine.
39 posts
Nice clean monotonic dataset. Your month-0 to month-4 jump is clearly outside CV (which is ~8-12% for fasting insulin at low baselines). Real signal, not noise.