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SHBG crashed on tirz — is that a problem?

S
Joined 2026
25 posts
slow_titrateMember
18d ago · 745 views

Baseline SHBG was 42 nmol/L. After 14 weeks on tirz 10mg/week, -28 lbs, SHBG is 24.

Total T unchanged (684 -> 702). Free T is higher now of course (lower SHBG + same total). Feel fine.

Is the crashed SHBG bad on its own, or is it just 'better insulin sensitivity -> lower SHBG' which is the expected story?

3 Replies

D
Joined 2025
119 posts
dr_doubtRegular
18d ago

SHBG CV is ~8-12% within person. 42 -> 24 is clearly outside noise so it's a real shift, but as cbc said, it's a predictable shift in a direction that usually means 'metabolism is healthier'.

C
Joined 2025
27 posts
cbc_cmpMember
18d ago

Lower SHBG on improved insulin sensitivity is the expected story. You're seeing the metabolic improvement, not something bad.

That said, SHBG 24 is on the lower end. If you feel fine, Free T is fine, estradiol in range, no acne/irritability — you're good. The number by itself isn't worth acting on.

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S
Joined 2026
25 posts
slow_titrateMember
17d ago

Alright. Filing under 'expected, not a problem'.

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