Sermorelin vs Ipamorelin — which actually feels like something

They're not the same compound class. Sermorelin is a GHRH analog — binds the GHRH receptor, releases GH only as much as the pituitary is ready to release. Weaker pulse, fewer side effects, very dependent on somatostatin tone.

Ipamorelin is a GHRP — ghrelin receptor agonist. Independent pathway. Actively 'gates open' the GH pulse past somatostatin, which is why the subjective effect is much stronger.

Stacking them is synergistic because you hit both receptors. Sermorelin alone is the weakest GHS compound for this reason.

Sermorelin standalone is really an 'entry drug' that shouldn't have been sold as a real GH protocol. The comparison to Ipa standalone is not close.

Your IGF delta confirms the mechanism. Sermorelin moved IGF 24 points in 8 weeks, Ipa moved it 61 points. Ipa is doing 2.5x the work at comparable dosing.

If you run them together — sermorelin + Ipa 300/200 3x daily — the IGF bump is bigger than either alone, often 80-100 points from baseline. The synergy is real, that's why CJC+Ipa (same mechanism pair) is the workhorse.

Fair but worth noting — sermorelin has a shorter half-life (~12 min) than CJC no-DAC (~30 min). Some of the weakness is kinetics, not just receptor selection. At matched pulse-profile sermorelin underperforms CJC but not by as much.

So next cycle I should be running CJC no-DAC + Ipa together rather than either alone. That's the consensus?

@new2peptides yes. CJC no-DAC 100 mcg + Ipa 200 mcg, 2-3x daily, pre-bed always. That's the standard newbie-appropriate GHS stack.