Hexarelin — the one nobody talks about honestly
205 posts
Hexarelin is a GHRP like Ipamorelin but it hits harder and bundles more side effects. Specifically:
- Strongest GH pulse of the GHRP class
- Also bumps prolactin and cortisol noticeably (unlike Ipa which is clean on both)
- Tachyphylaxis develops fast — within 2-3 weeks the GH response attenuates significantly
- Cardiac effects in rodent data are actually positive at low doses (cardioprotective) but this is not well-characterized in humans
At low dose (100 mcg or less) and in short cycles (2-3 weeks max) I think hexarelin has a niche — for people who've plateaued on Ipa and want a brief 'peak pulse' intervention. As a daily-driver GHRP it's a bad choice.
Anyone running it currently? What dose and cycle length?
- CJC-1295 no DAC · 100 mcg · pre-bed · sub-Q
- Ipamorelin · 200 mcg · pre-bed · sub-Q
- BPC-157 · 500 mcg · 2x/day · sub-Q
7 Replies
41 posts
Ran hexarelin 100 mcg 3x daily for 3 weeks as a finisher to an 8-week CJC+Ipa cycle. GH pulse was noticeably bigger (subjective, no venous sampling obviously) and then by week 3 was clearly dropping. Tachyphylaxis is real and fast. Quit and did 6 weeks off.
94 posts
Hexarelin as a 'finisher' for 2 weeks makes sense. As a main compound it's a mistake. The prolactin creep alone should disqualify it for most users.
- CJC-1295 no DAC · 100 mcg · pre-bed · sub-Q
- Ipamorelin · 200 mcg · pre-bed · sub-Q
- BPC-157 · 250 mcg · 2x/day · sub-Q
50 posts
Baseline prolactin at start of hex cycle, week 2, and week 4 in healthy males tends to go: 8 → 14 → 22 ng/mL. Not catastrophic but well into 'why is this on a GHS protocol' territory. Ipa does not do this.
36 posts
I ran hexarelin as my first GHRP back in 2019 because it was cheap. Gyno flare at week 4 that took 2 months to resolve. Not doing that again. Newbies should start with Ipa, not Hex.
- Tesamorelin · 1 mg · daily AM · sub-Q
205 posts
All confirming what I expected. Hex is basically in the 'interesting tool, wrong default choice' bucket. For 99% of users the right GHRP is Ipamorelin. Hex has a small niche for peak-pulse chasers running it 2 weeks at a time.
- CJC-1295 no DAC · 100 mcg · pre-bed · sub-Q
- Ipamorelin · 200 mcg · pre-bed · sub-Q
- BPC-157 · 500 mcg · 2x/day · sub-Q
115 posts
The cardioprotective rodent data people cite for hex is at doses that don't translate meaningfully to human protocols. Don't use 'it might be good for the heart' as a justification for hex — that evidence doesn't exist in humans.