Hexarelin — the one nobody talks about honestly
212 posts
Hexarelin is a GHRP like Ipamorelin but it hits harder and bundles more side effects. Specifically:
- Strongest GH pulse of the GHRP class
- Also bumps prolactin and cortisol noticeably (unlike Ipa which is clean on both)
- Tachyphylaxis develops fast — within 2-3 weeks the GH response attenuates significantly
- Cardiac effects in rodent data are actually positive at low doses (cardioprotective) but this is not well-characterized in humans
At low dose (100 mcg or less) and in short cycles (2-3 weeks max) I think hexarelin has a niche — for people who've plateaued on Ipa and want a brief 'peak pulse' intervention. As a daily-driver GHRP it's a bad choice.
Anyone running it currently? What dose and cycle length?
- CJC-1295 no DAC · 100 mcg · pre-bed · sub-Q
- Ipamorelin · 200 mcg · pre-bed · sub-Q
- BPC-157 · 500 mcg · 2x/day · sub-Q
8 Replies
43 posts
Ran hexarelin 100 mcg 3x daily for 3 weeks as a finisher to an 8-week CJC+Ipa cycle. GH pulse was noticeably bigger (subjective, no venous sampling obviously) and then by week 3 was clearly dropping. Tachyphylaxis is real and fast. Quit and did 6 weeks off.
97 posts
Hexarelin as a 'finisher' for 2 weeks makes sense. As a main compound it's a mistake. The prolactin creep alone should disqualify it for most users.
- CJC-1295 no DAC · 100 mcg · pre-bed · sub-Q
- Ipamorelin · 200 mcg · pre-bed · sub-Q
- BPC-157 · 250 mcg · 2x/day · sub-Q
51 posts
Baseline prolactin at start of hex cycle, week 2, and week 4 in healthy males tends to go: 8 → 14 → 22 ng/mL. Not catastrophic but well into 'why is this on a GHS protocol' territory. Ipa does not do this.
43 posts
I ran hexarelin as my first GHRP back in 2019 because it was cheap. Gyno flare at week 4 that took 2 months to resolve. Not doing that again. Newbies should start with Ipa, not Hex.
- Tesamorelin · 1 mg · daily AM · sub-Q
212 posts
All confirming what I expected. Hex is basically in the 'interesting tool, wrong default choice' bucket. For 99% of users the right GHRP is Ipamorelin. Hex has a small niche for peak-pulse chasers running it 2 weeks at a time.
- CJC-1295 no DAC · 100 mcg · pre-bed · sub-Q
- Ipamorelin · 200 mcg · pre-bed · sub-Q
- BPC-157 · 500 mcg · 2x/day · sub-Q
117 posts
The cardioprotective rodent data people cite for hex is at doses that don't translate meaningfully to human protocols. Don't use 'it might be good for the heart' as a justification for hex — that evidence doesn't exist in humans.
24 posts
Yeah the prolactin creep is real. I watched mine go from 9 to 18 in 3 weeks and that was enough to kill it for me, doesn't matter how hard it pulses GH if you're dealing with that noise. Ipa is boring but it actually lets you train without your nips being sore. The cardiac stuff everyone cites is cope, showmethestudy nailed it.