GH axis suppression fear — will GHS tank my natural production
25 posts
Worry that's been sitting in my head: if I run GHS for 8 weeks, does my pituitary 'forget how' to pulse GH on its own and I'm stuck needing exogenous support to feel right?
Seeing mixed things online. Some people say GHS is HPTA-neutral, others say long-term use suppresses endogenous production.
What's the real picture?
4 Replies
205 posts
Real picture: GHS does not cause durable HPG-axis-style shutdown the way exogenous rhGH can. GHS works via native pathways — you're stimulating your own pituitary to pulse, not replacing pituitary output.
Short-term (weeks post-cycle) there's some somatostatin rebound and reduced pulse amplitude for 2-4 weeks. That resolves. Long-term, no durable suppression has been shown in the GHS literature at the doses and cycles this community runs.
- CJC-1295 no DAC · 100 mcg · pre-bed · sub-Q
- Ipamorelin · 200 mcg · pre-bed · sub-Q
- BPC-157 · 500 mcg · 2x/day · sub-Q
115 posts
Long-term human data (>2 years continuous) on GHS is limited. 'No durable suppression shown' is accurate but partially because the studies aren't long enough. The cycle-on/cycle-off model is the risk-managed approach.
25 posts
This is what I needed to hear. 8wk on/4wk off and I'm probably fine. Thanks @hexaclinic.