GH axis suppression fear — will GHS tank my natural production
28 posts
Worry that's been sitting in my head: if I run GHS for 8 weeks, does my pituitary 'forget how' to pulse GH on its own and I'm stuck needing exogenous support to feel right?
Seeing mixed things online. Some people say GHS is HPTA-neutral, others say long-term use suppresses endogenous production.
What's the real picture?
5 Replies
212 posts
Real picture: GHS does not cause durable HPG-axis-style shutdown the way exogenous rhGH can. GHS works via native pathways — you're stimulating your own pituitary to pulse, not replacing pituitary output.
Short-term (weeks post-cycle) there's some somatostatin rebound and reduced pulse amplitude for 2-4 weeks. That resolves. Long-term, no durable suppression has been shown in the GHS literature at the doses and cycles this community runs.
- CJC-1295 no DAC · 100 mcg · pre-bed · sub-Q
- Ipamorelin · 200 mcg · pre-bed · sub-Q
- BPC-157 · 500 mcg · 2x/day · sub-Q
117 posts
Long-term human data (>2 years continuous) on GHS is limited. 'No durable suppression shown' is accurate but partially because the studies aren't long enough. The cycle-on/cycle-off model is the risk-managed approach.
28 posts
This is what I needed to hear. 8wk on/4wk off and I'm probably fine. Thanks @hexaclinic.
8 posts
nah I think the "no durable suppression" line is doing a lot of heavy lifting here. most of those studies are short term and on people who aren't stacking it with other stuff. real world you're probably running this with other peptides or gear and the interactions aren't well understood. plus even if pituitary function bounces back in 4 weeks, what about the actual GH secretory capacity? can't find good data on whether your somatotroph cells stay responsive long term after repeated stimulation cycles. maybe they do, maybe they don't