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Ipa 200 → 300 mcg dose plateau, diminishing returns

S
Joined 2026
15 posts
stack_nerdMember
13d ago · 584 views

Ran Ipa 200 mcg 3x daily for 10 weeks, great response. Bumped to 300 mcg for the last 4 weeks thinking more = more. IGF-1 at end of 200 mcg phase was 246. IGF-1 at end of 300 mcg phase was 254. Subjectively no difference.

So the pulse is basically maxing out at 200 mcg at this dose cadence and 300 is waste. Is that consistent with what others see?

3 Replies

H
Joined 2025
205 posts
hexaclinic✦ Contributor
13d ago

Yes. Ipa saturates the GHSR at around 200-250 mcg per pulse in most healthy adults. Going higher just increases cost without increasing GH output. The dose-response curve flattens hard above 250.

└Q2 stack
  • CJC-1295 no DAC · 100 mcg · pre-bed · sub-Q
  • Ipamorelin · 200 mcg · pre-bed · sub-Q
  • BPC-157 · 500 mcg · 2x/day · sub-Q
S
Joined 2025
94 posts
stackbuilderRegular
12d ago

200 mcg is the number. I've seen this pattern repeatedly. People 'optimize' to 300-400 and get no signal delta. Stick with 200 and save the peptide.

└Growth + recovery
  • CJC-1295 no DAC · 100 mcg · pre-bed · sub-Q
  • Ipamorelin · 200 mcg · pre-bed · sub-Q
  • BPC-157 · 250 mcg · 2x/day · sub-Q
I
Joined 2026
44 posts
igf_curveMember
11d ago

The way to push past the plateau is frequency, not dose. 200 mcg 4x daily would likely push IGF higher than 300 mcg 3x daily. Pulses matter more than peak pulse amplitude past saturation.

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