Ipa 200 → 300 mcg dose plateau, diminishing returns
16 posts
Ran Ipa 200 mcg 3x daily for 10 weeks, great response. Bumped to 300 mcg for the last 4 weeks thinking more = more. IGF-1 at end of 200 mcg phase was 246. IGF-1 at end of 300 mcg phase was 254. Subjectively no difference.
So the pulse is basically maxing out at 200 mcg at this dose cadence and 300 is waste. Is that consistent with what others see?
4 Replies
212 posts
Yes. Ipa saturates the GHSR at around 200-250 mcg per pulse in most healthy adults. Going higher just increases cost without increasing GH output. The dose-response curve flattens hard above 250.
- CJC-1295 no DAC · 100 mcg · pre-bed · sub-Q
- Ipamorelin · 200 mcg · pre-bed · sub-Q
- BPC-157 · 500 mcg · 2x/day · sub-Q
97 posts
200 mcg is the number. I've seen this pattern repeatedly. People 'optimize' to 300-400 and get no signal delta. Stick with 200 and save the peptide.
- CJC-1295 no DAC · 100 mcg · pre-bed · sub-Q
- Ipamorelin · 200 mcg · pre-bed · sub-Q
- BPC-157 · 250 mcg · 2x/day · sub-Q
40 posts
Curve flattening is real but igf_curve is pushing the frequency angle hard without showing the work. More pulses just means more total peptide use, which defeats the whole point of finding your saturation dose. Your data is clean, 200 mcg works, stick with it. The people chasing optimization past that point are just burning money.