Cycle structure — 8 on / 4 off vs 4 on / 2 off
18 posts
Standard GHS cycle advice is 8 weeks on, 4 weeks off. But I've seen some protocols running 4 on / 2 off on rotation. Is the 8/4 cadence evidence-based or just community convention?
3 Replies
41 posts
Convention more than evidence. 8/4 is a reasonable default but 4/2 achieves similar IGF average with less time blunted off-cycle. The 'right' answer depends on goal and receptor sensitivity over time.
205 posts
For GHSR compounds (GHRPs), shorter on-phases preserve receptor sensitivity better — 4/2 is arguably better than 8/4 for pure pulse preservation. For GHRH analogs, it matters less. Most people run mixed stacks so 8/4 or 6/3 are sane compromises.
- CJC-1295 no DAC · 100 mcg · pre-bed · sub-Q
- Ipamorelin · 200 mcg · pre-bed · sub-Q
- BPC-157 · 500 mcg · 2x/day · sub-Q
46 posts
I ran 4/2 for a year and my IGF trend was more stable than the 8/4 years. Fewer peak/trough swings, more consistent sleep effect.