Fine lines around eyes — is GHK-Cu actually doing anything or is this placebo

P
Joined 2026
36 posts
1/21/2026 · 718 views

4 months in on 0.1% GHK-Cu serum under eyes. I think the fine lines look softer but I'm honestly not sure if that's the peptide, the moisturizer I also started, or me staring at myself in better lighting. No before photos because I'm a fool.

What's realistic for this peptide at this concentration? Am I expecting too much in 4 months, or is this where most people plateau?

6 Replies

H
Joined 2025
212 posts
hexaclinicContributor
1/21/2026

Realistic expectation: modest improvement in skin thickness and hydration over 8–16 weeks, visible fine line softening in some people, nothing dramatic. If you were expecting retinoid-level results you're on the wrong compound.

Q2 stack
  • CJC-1295 no DAC · 100 mcg · pre-bed · sub-Q
  • Ipamorelin · 200 mcg · pre-bed · sub-Q
  • BPC-157 · 500 mcg · 2x/day · sub-Q
T
Joined 2025
68 posts
theoreticRegular
1/22/2026

4 months is fine. You're not going to get more result at 12 months than you got at 6. If you're seeing anything at all, that's the effect.

Longevity
  • Epithalon · 10 mg · 10d on / 80d off · sub-Q
  • MOTS-c · 5 mg · 2x/wk · sub-Q
  • 5-Amino-1MQ · 150 mg · daily · oral
P
Joined 2026
36 posts
1/23/2026

Okay, so 'modest improvement' is where I am. Good to calibrate expectations.

R
Joined 2025
43 posts
1/26/2026

GHK-Cu is a supporting actor, not a lead. It earns its place in a routine that also has retinoid and sunscreen, not as a standalone anti-aging tool.

Current
  • Tesamorelin · 1 mg · daily AM · sub-Q
L
Joined 2025
37 posts
4/22/2026

Yeah the thing is you need retinoids to actually move the needle on fine lines. GHK-Cu is nice for skin barrier and collagen support but it's not going to erase anything on its own. That said, if you're already using a retinoid and sunscreen religiously then yeah it probably adds something, just don't expect it to be your star player. Most people who see real results are stacking it with other stuff, not running it solo.

Research cycle
  • MOTS-c · 10 mg · weekly · sub-Q
  • 5-Amino-1MQ · 100 mg · daily AM · oral
M
Joined 2026
41 posts
motsc_opsMember
4/28/2026

Honestly the moisturizer is probably doing half the work here. GHK-Cu needs retinoids to actually matter for fine lines, people just don't want to hear that.

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