Dihexa — is anyone actually using this safely?
16 posts
Dihexa keeps getting hyped (angiotensin IV analog, allegedly 7 orders of magnitude more potent than BDNF for synaptogenesis on paper, oral bioavailability). I have exactly zero trust in the 'more potent than BDNF' figure because it's always cited without the original in vitro context.
What I cannot find: any clean human write-up. The half-life discussions range from 'hours' to 'two days' depending on who's posting. Oral dose floats between 8 mg and 25 mg/day with no consensus.
Is anyone running this and tracking anything concrete? Or is this a case where everyone quietly dropped it and moved on?
8 Replies
117 posts
The '7 orders of magnitude more potent than BDNF' comes from a specific in vitro synaptogenesis assay in a Hal lab paper. It is not a claim about in vivo cognitive effect. Comparing peptide potency across assays and then claiming it holds in a human brain is category error.
212 posts
I ran it. 8mg oral, 2 weeks. Felt nothing. Dropped it. Sample size 1, but I notice most peptides at all and noticed this one exactly zero.
- CJC-1295 no DAC · 100 mcg · pre-bed · sub-Q
- Ipamorelin · 200 mcg · pre-bed · sub-Q
- BPC-157 · 500 mcg · 2x/day · sub-Q
34 posts
What @showmethestudy said. The original paper is real and interesting. The marketing around Dihexa isn't. Absence of human safety data is not 'too new,' it's 'nobody's run a trial.'
16 posts
Looks like the consensus is 'probably do not run this until there's real human data.' That tracks with my gut.
68 posts
This is the class of compound where if it worked as advertised at the doses described, we'd see more consistent anecdotal signal. The fact that nobody ever writes a compelling Dihexa log should tell you something.
- Epithalon · 10 mg · 10d on / 80d off · sub-Q
- MOTS-c · 5 mg · 2x/wk · sub-Q
- 5-Amino-1MQ · 150 mg · daily · oral
20 posts
I keep an eye on Dihexa threads every 6 months or so. Same 3 questions, same lack of answers. That pattern by itself is a data point.
21 posts
Ran it for like 4 weeks at 15mg daily subq actually. Couldn't tell shit from shinola, no noticeable cognition bump, no sides either. The problem is you're right about the data desert, there's literally nothing to anchor dosing on so half the people are probably underdosing and the other half are just throwing money at their piss. I'd wait for someone with actual resources to run a proper PK study before getting hyped, this feels like one of those compounds that looks magic in a petri dish and does basically nothing in a real human.