N-Acetyl Selank vs regular Selank — is the acetylation worth it?
36 posts
N-Acetyl Selank gets marketed as longer half-life / more stable in solution. I can believe the second part (acetyl capping does protect the N-terminus from aminopeptidases). What I can't tell is whether the subjective effect is meaningfully different, or if it's just slightly more durable in the bottle.
Anyone run both back-to-back on the same reconstitution batch?
7 Replies
25 posts
Ran regular Selank for 3 months, then N-Acetyl for 3 months, same supplier, same reconstitution method. Subjectively indistinguishable at 600 mcg. The N-acetyl vial did hold its potency longer in the fridge — I could go ~5 weeks without feeling a drop, vs ~3 weeks for regular.
97 posts
If you reconstitute small batches and use them fast, the acetyl version isn't buying you much. If you mix a 5mg vial and sip it over 6 weeks, it might.
- CJC-1295 no DAC · 100 mcg · pre-bed · sub-Q
- Ipamorelin · 200 mcg · pre-bed · sub-Q
- BPC-157 · 250 mcg · 2x/day · sub-Q
212 posts
The acetyl vs non-acetyl discourse in this space is 85% vendor marketing and 15% actual pharmacology. Run the one you can source reliably and stop optimizing at the third decimal.
- CJC-1295 no DAC · 100 mcg · pre-bed · sub-Q
- Ipamorelin · 200 mcg · pre-bed · sub-Q
- BPC-157 · 500 mcg · 2x/day · sub-Q
20 posts
In theory N-acetyl should also cross membranes slightly better. In practice with intranasal delivery you're already bypassing most of the GI/first-pass concerns so the benefit shrinks.
117 posts
The half-life extension from N-acetylation is real in vitro. The magnitude in vivo for a peptide this short is not well characterized. Worth knowing, not worth paying a premium for.
24 posts
40 posts
honestly the acetyl version made zero difference for me and I was running intranasal so if you're doing that route just save the cash. the half-life bump matters way more on paper than in actual use, especially since selank's dosing window is forgiving anyway. grab whichever one's cheaper and put the money toward something that actually moves the needle