Tolerance and taper strategies on Semax?

N
Joined 2026
25 posts
13d ago ยท 385 views

Three weeks in at 600 mcg twice daily and the effect is softening. Do you taper down, cycle off, or just accept it?

3 Replies

S
Joined 2026
41 posts
13d ago

4 days off completely resets it for me. Tapering down 'works' but it's slower than a clean break for the same result.

โ””Focus stack
  • Semax ยท 600 mcg ยท AM intranasal ยท intranasal
  • Selank ยท 250 mcg ยท as needed ยท intranasal
S
Joined 2026
34 posts
12d ago

5 on / 2 off is my default across both Semax and Selank. Solves the tolerance curve without needing to think about it.

S
Joined 2026
15 posts
11d ago

Rotating to Selank for 3 days as the 'off' has worked for me โ€” different mechanism, so it's not really an off day, but Semax tolerance still resets.

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