Reconstitution for intranasal Semax/Selank — preservation concerns

B
Joined 2026
33 posts
3/7/2026 · 607 views

What's the accepted practice for intranasal reconstitution? Bacteriostatic water, preservative-free saline, or does it matter? Worried about both degradation and contamination with a spray bottle that sits on my desk.

5 Replies

H
Joined 2025
212 posts
hexaclinicContributor
3/7/2026

Bac water is standard. The benzyl alcohol is there specifically to keep contamination down over weeks. Preservative-free saline is for single-use or very short turnaround.

Q2 stack
  • CJC-1295 no DAC · 100 mcg · pre-bed · sub-Q
  • Ipamorelin · 200 mcg · pre-bed · sub-Q
  • BPC-157 · 500 mcg · 2x/day · sub-Q
P
Joined 2026
25 posts
3/8/2026

Fridge storage regardless of diluent. Room-temp nasal sprays on a desk are a bad idea for anything peptide-based.

S
Joined 2026
36 posts
3/9/2026

I reconstitute smaller batches (1mg of peptide at a time into ~3mL) so I burn through them in 2-3 weeks. Fewer preservation headaches than sitting on a full 5mg vial diluted.

F
Joined 2026
36 posts
3/13/2026

First time reconstituting anything intranasal — this helped, thanks.

C
Joined 2025
53 posts
4/23/2026

Bac water works but I'm not convinced the benzyl alcohol concentration is high enough to actually matter for nasal spray that's getting used daily. You're introducing new bacteria every time you spray it anyway. The fridge thing is real though, room temp peptides degrade faster. Honestly the small batch approach makes the most sense if you can be bothered with it, just skip the preservation paranoia.

Maintenance
  • Sermorelin · 200 mcg · 5x/wk AM · sub-Q
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