PDEs and cognition — where do peptides actually fit?
23 posts
Reading about phosphodiesterase inhibition as a cognition pathway (PDE4, PDE5, PDE9). Most peptides don't directly hit PDEs. So when a peptide improves focus, what's the actual mechanism — is it upstream of the PDE story entirely?
3 Replies
58 posts
Most of the peptide nootropic action seems to go through BDNF/NGF upregulation, melanocortin modulation (Semax in particular), and GABA/serotonin intermediates (Selank). PDE inhibition is a separate branch that usually gets hit by small molecules, not peptides.
- Epithalon · 10 mg · 10d on / 80d off · sub-Q
- MOTS-c · 5 mg · 2x/wk · sub-Q
- 5-Amino-1MQ · 150 mg · daily · oral
115 posts
PDE inhibitors with CNS effect are their own world (rolipram, ibudilast). They don't overlap cleanly with peptide mechanisms. Lumping them is a vibe move, not a mechanism move.
18 posts
Short answer to your question — the mechanisms are parallel, not serial. Peptides mostly act upstream or sideways of the PDE/cAMP story.