NAD+ precursors alongside MOTS-c — does this stack make sense?
31 posts
The theory: MOTS-c is a mitochondrial-derived peptide with effects partially downstream of cellular energetics; NR/NMN raise NAD+ pools which feed into the same machinery. On paper, complementary.
In practice I'm not sure I can distinguish one from the other when running both, and NMN is expensive enough that I want to know if it's actually adding value.
Current: 500mg NMN AM sublingual, MOTS-c 10mg 2x/week. 3 months in.
Anyone split-tested? Anyone run NAD+ IVs alongside peptides? Waste of money or actually different?
12 Replies
205 posts
NAD+ IVs are almost certainly a waste of money for the goal you're describing. Bioavailability of oral NR is okay and of sublingual NMN is decent. The IV adds cost and a tiny bit of peak, not much AUC.
- CJC-1295 no DAC · 100 mcg · pre-bed · sub-Q
- Ipamorelin · 200 mcg · pre-bed · sub-Q
- BPC-157 · 500 mcg · 2x/day · sub-Q
115 posts
NMN oral trials in humans are underwhelming for the price. Tissue NAD+ rises a bit, functional outcomes are mixed. If you're going to spend here spend on labs not precursors.
31 posts
Useful. Dropping NMN for 8 weeks to see what happens, keeping MOTS-c. Will report back.
26 posts
Anecdotally I notice NMN when I stop it after long use. Sleep worsens slightly for a week. Not sure what that says about whether it "works" — could be habituation.
71 posts
One thing worth noting: NMN in the US is now in a regulatory limbo that might affect sourcing quality. Check your source's purity testing.
50 posts
If you can, measure whole-blood NAD+ before and after. Labs are expensive (~$150) but it's the only way to know if your precursor is doing what you paid for.
31 posts
Been thinking about that. Going to run 8 weeks NR after the washout so I can compare to my NMN period. Messy n=1 but better than nothing.
22 posts
Anyone compared NMN to NR head to head? My read is NR is better-studied and cheaper, but NMN has the marketing.
22 posts
This is the level of methodological care I wish more longevity posts had.
31 posts
The other thing I'd measure if you're running NAD+ precursors is homocysteine. Methyl group consumption in the NAD+ salvage pathway isn't free.
12 posts
Seconded. I've seen HCY creep up in 2 of 4 people I know who went on daily NMN without B-vitamin support. Not dramatic but measurable.