Expected Tesamorelin to work for visceral fat and it didn't (much)

D
Joined 2026
45 posts
3/17/2026 ยท 815 views

Ran Tesamorelin 2mg/day for 16 weeks. Main goal: visceral fat reduction (DEXA confirmed slight VAT elevation pre-cycle).

Pre: VAT 1.2kg. Post: VAT 1.05kg. Statistically meh.

Side effects were real (fluid retention, some joint stiffness, FBG drift up). Lipids unchanged.

Expected this to be a home run based on the HIV lipodystrophy data. It wasn't. Maybe I was under-VAT to begin with for the drug to show significant effect. Maybe 16 weeks wasn't long enough.

Anyone else have a "I expected this to work and it didn't" experience with Tes?

7 Replies

I
Joined 2026
44 posts
igf_curveMember
3/18/2026

Tesamorelin trials were in people with substantial VAT. Modest effect in people with modest VAT is actually consistent with the data. Drug works best where there's a lot to work on.

H
Joined 2026
33 posts
3/19/2026

The FBG drift is predictable for any GHRH analog. Not a Tesamorelin-specific failure, just the GH/insulin problem again.

S
Joined 2025
94 posts
28d ago

At that VAT level diet and training probably would have moved the needle more than Tes. Not a popular answer.

โ””Growth + recovery
  • CJC-1295 no DAC ยท 100 mcg ยท pre-bed ยท sub-Q
  • Ipamorelin ยท 200 mcg ยท pre-bed ยท sub-Q
  • BPC-157 ยท 250 mcg ยท 2x/day ยท sub-Q
D
Joined 2026
45 posts
27d ago

Yeah, in retrospect I didn't need the drug. Using it as a VAT tool in someone with moderate VAT was wrong tool wrong target.

S
Joined 2026
25 posts
22d ago

Appreciate the honesty on a negative result. More of this, less of the 'miracle peptide' posts.

F
Joined 2026
23 posts
19d ago

Tes at 2mg is the standard lipodystrophy dose. Did you consider a higher dose for a shorter cycle to see if the signal strengthens?

D
Joined 2026
45 posts
18d ago

I didn't. Tempted but not enough to justify the side effect burden given the modest VAT target to begin with.

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