Expected Tesamorelin to work for visceral fat and it didn't (much)

D
Joined 2026
47 posts
3/17/2026 ยท 848 views

Ran Tesamorelin 2mg/day for 16 weeks. Main goal: visceral fat reduction (DEXA confirmed slight VAT elevation pre-cycle).

Pre: VAT 1.2kg. Post: VAT 1.05kg. Statistically meh.

Side effects were real (fluid retention, some joint stiffness, FBG drift up). Lipids unchanged.

Expected this to be a home run based on the HIV lipodystrophy data. It wasn't. Maybe I was under-VAT to begin with for the drug to show significant effect. Maybe 16 weeks wasn't long enough.

Anyone else have a "I expected this to work and it didn't" experience with Tes?

8 Replies

I
Joined 2026
45 posts
igf_curveMember
3/18/2026

Tesamorelin trials were in people with substantial VAT. Modest effect in people with modest VAT is actually consistent with the data. Drug works best where there's a lot to work on.

H
Joined 2026
35 posts
3/19/2026

The FBG drift is predictable for any GHRH analog. Not a Tesamorelin-specific failure, just the GH/insulin problem again.

S
Joined 2025
97 posts
3/21/2026

At that VAT level diet and training probably would have moved the needle more than Tes. Not a popular answer.

โ””Growth + recovery
  • CJC-1295 no DAC ยท 100 mcg ยท pre-bed ยท sub-Q
  • Ipamorelin ยท 200 mcg ยท pre-bed ยท sub-Q
  • BPC-157 ยท 250 mcg ยท 2x/day ยท sub-Q
D
Joined 2026
47 posts
3/23/2026

Yeah, in retrospect I didn't need the drug. Using it as a VAT tool in someone with moderate VAT was wrong tool wrong target.

S
Joined 2026
29 posts
3/27/2026

Appreciate the honesty on a negative result. More of this, less of the 'miracle peptide' posts.

F
Joined 2026
24 posts
3/30/2026

Tes at 2mg is the standard lipodystrophy dose. Did you consider a higher dose for a shorter cycle to see if the signal strengthens?

D
Joined 2026
47 posts
3/31/2026

I didn't. Tempted but not enough to justify the side effect burden given the modest VAT target to begin with.

T
Joined 2025
68 posts
theoreticRegular
5/2/2026

Honestly this is refreshing to see. Most people who run peptides don't come back and say "yeah that sucked" so you're already ahead. The HIV data looks incredible on paper but those guys had like 30+ kg VAT and full lipodystrophy, completely different animal than chasing the last bit of belly fat. Tes might just be a tool for people with actual metabolic dysfunction, not optimization for already-decent body composition.

โ””Longevity
  • Epithalon ยท 10 mg ยท 10d on / 80d off ยท sub-Q
  • MOTS-c ยท 5 mg ยท 2x/wk ยท sub-Q
  • 5-Amino-1MQ ยท 150 mg ยท daily ยท oral
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