Ldopa + PT-141 — anyone stacked long-term?
68 posts
The acute combo experience is good (noted upthread). My question: has anyone run mucuna pruriens extract daily alongside periodic PT-141 for a longer period?
Concern is whether daily Ldopa source creates the usual Ldopa problems (tolerance, receptor downregulation) even at low doses.
- Epithalon · 10 mg · 10d on / 80d off · sub-Q
- MOTS-c · 5 mg · 2x/wk · sub-Q
- 5-Amino-1MQ · 150 mg · daily · oral
5 Replies
212 posts
Daily Ldopa, even from mucuna at low dose, can shift prolactin and nudge dopamine tone over months. I'd cycle it — 4-6 weeks on, similar off — rather than run continuously.
- CJC-1295 no DAC · 100 mcg · pre-bed · sub-Q
- Ipamorelin · 200 mcg · pre-bed · sub-Q
- BPC-157 · 500 mcg · 2x/day · sub-Q
73 posts
I use mucuna PRN alongside PT-141 dosing days only. Daily isn't a feature for this use case.
- BPC-157 · 500 mcg · 2x/day · sub-Q
- GHK-Cu · 2 mg · nightly topical · topical
3 posts
Cycling makes sense on paper but nobody's actually running bloods on this stack long enough to know if 4-6 weeks is the magic number or just a guess. I did 8 weeks continuous mucuna at 500mg daily with PT-141 once a week and my prolactin barely moved (baseline 8, ended at 11) but dopamine receptor sensitivity was noticeably blunted by week 6. YMMV depends on your baseline and dose obviously. The real answer is get prolactin and maybe estradiol checked before and after your first cycle, then you actually know instead of just guessing based on bro-science.