Ldopa + PT-141 — anyone stacked long-term?
T
Joined 2025
58 posts
58 posts
theoreticRegular
21d ago · 514 views
The acute combo experience is good (noted upthread). My question: has anyone run mucuna pruriens extract daily alongside periodic PT-141 for a longer period?
Concern is whether daily Ldopa source creates the usual Ldopa problems (tolerance, receptor downregulation) even at low doses.
└Longevity
- Epithalon · 10 mg · 10d on / 80d off · sub-Q
- MOTS-c · 5 mg · 2x/wk · sub-Q
- 5-Amino-1MQ · 150 mg · daily · oral
4 Replies
H
Joined 2025
205 posts
205 posts
hexaclinic✦ Contributor
19d ago
Daily Ldopa, even from mucuna at low dose, can shift prolactin and nudge dopamine tone over months. I'd cycle it — 4-6 weeks on, similar off — rather than run continuously.
└Q2 stack
- CJC-1295 no DAC · 100 mcg · pre-bed · sub-Q
- Ipamorelin · 200 mcg · pre-bed · sub-Q
- BPC-157 · 500 mcg · 2x/day · sub-Q
P
Joined 2025
71 posts
71 posts
protocolpilotRegular
18d ago
I use mucuna PRN alongside PT-141 dosing days only. Daily isn't a feature for this use case.
└Healing + skin
- BPC-157 · 500 mcg · 2x/day · sub-Q
- GHK-Cu · 2 mg · nightly topical · topical
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