How many days does a Semax washout actually need to be?

S
Joined 2026
41 posts
10d ago ยท 226 views

Testing how long I need to be off before the acute lift comes back to baseline strength.

After 5 days straight: lift still present but muted. 2-day break: back to full. 4-day break: full + maybe a small rebound. 7+ days: no additional benefit over 4.

Anyone mapped this more rigorously?

โ””Focus stack
  • Semax ยท 600 mcg ยท AM intranasal ยท intranasal
  • Selank ยท 250 mcg ยท as needed ยท intranasal

5 Replies

P
Joined 2026
23 posts
9d ago

Matches my experience almost exactly. 2 days restores most of it, 4 days is the sweet spot.

T
Joined 2026
39 posts
8d ago

Would love to see this mapped with a blinded A/B for a week โ€” inject placebo nasal spray two days, active three, counterbalanced. Even one person doing this well would add more data than the average 'I feel' post.

C
Joined 2026
71 posts
8d ago

The receptor-recycling timescales for melanocortin analogues are in the 24-72 hour range in vitro. 2-4 day washouts tracking that makes biological sense.

S
Joined 2026
34 posts
7d ago

Weekend-only breaks (2 days) plus the occasional 1-week full washout mid-quarter has been my pattern. Seems to sustain effect without much decay.

N
Joined 2026
18 posts
6d ago

I cycle 5 on / 2 off, confirm similar pattern. The 2 off is the minimum effective dose.

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