Cold-induced thermogenesis + MOTS-c for body comp — are they redundant?
41 posts
Mentioned in the main cold thread but want a dedicated discussion. Both cold exposure and MOTS-c work, roughly, on the mitochondrial biogenesis axis. Is doing both additive, redundant, or are they attacking different things?
My gut: overlapping but not identical mechanisms. Probably additive with diminishing returns.
6 Replies
212 posts
Partially overlapping. Cold activates BAT and systemic sympathetic response, MOTS-c acts more directly at the mitochondrial/AMPK layer. Additive in principle.
- CJC-1295 no DAC · 100 mcg · pre-bed · sub-Q
- Ipamorelin · 200 mcg · pre-bed · sub-Q
- BPC-157 · 500 mcg · 2x/day · sub-Q
117 posts
At this level of granularity most people can't distinguish additive from redundant experimentally. The question is more "can you afford to do both" than "is one necessary."
68 posts
Would love a split-test but the signal-to-noise for most home users is too poor. Accepting "probably additive with diminishing returns" as the working assumption.
- Epithalon · 10 mg · 10d on / 80d off · sub-Q
- MOTS-c · 5 mg · 2x/wk · sub-Q
- 5-Amino-1MQ · 150 mg · daily · oral
16 posts
Good summary of where the field actually is: mechanism-overlapping interventions that compound sometimes, can't isolate often, and probably both have ceiling effects.
- IGF-1 LR3 · 30 mcg · post-workout · sub-Q
- CJC-1295 no DAC · 100 mcg · pre-bed · sub-Q
- Ipamorelin · 200 mcg · pre-bed · sub-Q
- MGF (PEG) · 200 mcg · post-workout · sub-Q
32 posts
Cold is free once you have a tub, MOTS-c isn't. I'd start with cold and only add MOTS-c if you want to push further.
- BPC-157 · 500 mcg · 2x/day local to knee · sub-Q
- TB-500 · 5 mg · weekly loading · sub-Q
9 posts
ran cold + mots-c for like 8 weeks back to back and honestly didn't notice much difference splitting them vs just doing cold consistently. the cold alone was doing heavy lifting for me on body comp so adding the peptide felt kinda redundant in hindsight. ymmv obviously but I think nopain's take is right, start with the free thing and only stack if you're already dialed in on sleep and training.