Retatrutide log — stopping early, side effects (week 5)

R
Joined 2026
26 posts
3/2/2026 · 1905 views

Starting a reta log. 45F, 5'4", 198 lb. Want to lose 45 lb. Have tried sema (worked but plateaued at 178) and tirz (worked but plateaued at 172). Going full experiment with reta.

Starting dose: 2mg/week. Plan to titrate by 1mg every 4 weeks.

11 Replies

G
Joined 2026
32 posts
3/9/2026

Reta at 2mg hits harder than sema at 1mg or tirz at 5mg for most people. Titrate slower than you think.

R
Joined 2026
26 posts
3/9/2026

Week 1: 195.2. Dropped 2.8 lb in a week which is more than I ever saw on the others. Nausea is real, about 48h.

R
Joined 2026
26 posts
3/16/2026

Week 2: 191.0. Nausea stuck around longer than last week — more like 72h this time. Stomach cramping at 4am two nights in a row.

S
Joined 2026
8 posts
sulfur_shrugNew Member
3/16/2026

The 4am cramping is not a normal side effect profile. Consider dropping to 1mg.

R
Joined 2026
26 posts
26d ago

Week 3: 188.1. Dropped to 1mg as suggested. Cramping gone after the lower dose, nausea back to mild.

G
Joined 2026
32 posts
19d ago

RHR bump on reta is real for a minority. It's an off-target effect. If it doesn't come down this week I'd stop.

R
Joined 2026
26 posts
19d ago

Week 4: 186.8. Heart rate elevated for a few days (Oura showing RHR jumped from 62 to 74). That freaked me out.

R
Joined 2026
26 posts
10d ago

Week 5: RHR still 72. Not coming down. Stopping today. Down 11.2 lb in 5 weeks but this isn't worth messing with my cardiovascular system for. Will probably go back to tirz microdose for maintenance.

H
Joined 2025
205 posts
hexaclinicContributor
10d ago

Making the right call. Posted early-stop logs are more valuable than a lot of successful ones.

Q2 stack
  • CJC-1295 no DAC · 100 mcg · pre-bed · sub-Q
  • Ipamorelin · 200 mcg · pre-bed · sub-Q
  • BPC-157 · 500 mcg · 2x/day · sub-Q
C
Joined 2025
46 posts
9d ago

Exactly the right call and thanks for posting it. This is what the 'stop criteria' question in the template is for.

Maintenance
  • Sermorelin · 200 mcg · 5x/wk AM · sub-Q
  • BPC-157 · 250 mcg · 2x/day · sub-Q
F
Joined 2026
30 posts
9d ago

Reta isn't for everyone. You'll probably do great on tirz micro for hold. Good luck.

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