Ipamorelin vs Hexarelin — when would you actually pick hexarelin
50 posts
Hexarelin is the strongest GHRP in terms of pulse magnitude. Ipa is the cleanest in terms of selectivity (no prolactin, no cortisol, no ghrelin hunger bump to speak of at low doses). So: when is hexarelin worth its downsides?
My short list:
- Acute injury / tendon crisis where you want maximum pulse for weeks.
- Short 2-3 week cycles where desensitization is a non-issue.
- People who don't respond to Ipa (yes, they exist).
Case against hexarelin for most use cases: cortisol bump, prolactin bump, rapid desensitization, mood effects in some users. For chronic / long-cycle use, Ipa wins.
Anyone using hexarelin strategically?
11 Replies
212 posts
I've used hexarelin for 2-week pulses during rehab blocks. Works well. I never run it longer than that. Desensitization is very real and you lose the tool.
- CJC-1295 no DAC · 100 mcg · pre-bed · sub-Q
- Ipamorelin · 200 mcg · pre-bed · sub-Q
- BPC-157 · 500 mcg · 2x/day · sub-Q
97 posts
Short acute-injury window is exactly where I reach for hexarelin. 2-3 weeks at 200mcg 2x, on top of a healing compound like BPC. After that I rotate out. Past week 3 the cortisol bump shows up and the gain is smaller than the cost.
- CJC-1295 no DAC · 100 mcg · pre-bed · sub-Q
- Ipamorelin · 200 mcg · pre-bed · sub-Q
- BPC-157 · 250 mcg · 2x/day · sub-Q
43 posts
Ipa non-responders are a real subset. My wife is one — Ipa at 300mcg did almost nothing for her sleep or recovery. Hexarelin at 150 was obvious. Some receptor variation explains it.
45 posts
The prolactin bump on hexarelin is worth flagging for men prone to prolactin-sensitive sides. Doesn't happen to everyone but when it does you notice. Low-dose caber is an option but at that point your stack is getting convoluted.
71 posts
The Raun 1998 data showed hexarelin's pulse is ~2-3x larger than ipamorelin at matched doses. The receptor tachyphylaxis kicks in harder though, so AUC at week 4 converges.
52 posts
Used hexarelin for 3 weeks post-op on my rotator. No ipa on top. Pulse felt very strong, sleep was deep the first week. Week 3 it was clearly waning. Rotated to ipa + CJC after. Strategy worked well.
- BPC-157 · 250 mcg · 2x/day local · sub-Q
- TB-500 · 2 mg · weekly · sub-Q
24 posts
32 posts
Old-head here, hexarelin was the default before ipa hit the scene. The reason ipa won isn't that hexarelin stopped working — it's that clean pulses with no sides are easier to sustain over long cycles. For a 3-week hammer, hex still has a place.
- BPC-157 · 500 mcg · 2x/day local to knee · sub-Q
- TB-500 · 5 mg · weekly loading · sub-Q
50 posts
Great responses, about where my priors were. Summary: hexarelin is a specialty tool for short windows, Ipa is the workhorse. Anyone running hexarelin for 4+ weeks is probably leaving value on the table.
30 posts
ran hex for like 6 weeks once and yeah the desensitization thing is real, not just bro talk. first two weeks were nutty, by week 4 i was basically running it for the placebo effect lol. but honestly the cortisol bump never bothered me, my mood was fine, just the efficacy cliff was brutal. switched to ipa and it was like night and day because you don't get that wall. though i will say the guys saying "specialty tool" are right, if i ever blow out something again im definitely doing a short hex run because that acute injury window is when you actually want max stimulus, not steady state maintenance