Changed my mind on AOD-9604 — I was wrong to write it off
122 posts
Posted a year ago calling AOD-9604 useless. Standing by most of that take — it's not a meaningful fat-loss compound on its own and the obesity trial failures are real.
But a specific use case changed my mind: joint/cartilage-adjacent applications. There's a separate body of work on AOD-9604 for osteoarthritis and cartilage support that I wasn't engaging with. Ran it locally around a chronic AC joint issue for 4 weeks, pain curve moved in a way that other stuff hadn't.
So: AOD-9604 for fat loss — no. AOD-9604 as an adjunct for joint/cartilage issues — maybe, and worth a look.
Posting the update because I was confidently wrong on the second use case.
10 Replies
117 posts
Respect for the update. The cartilage/joint work on AOD is underappreciated. Still not fat-loss efficacy.
97 posts
The AC joint use case matches a niche I've seen. Local pin (not systemic) is key. Systemic AOD for joints would be diluted.
- CJC-1295 no DAC · 100 mcg · pre-bed · sub-Q
- Ipamorelin · 200 mcg · pre-bed · sub-Q
- BPC-157 · 250 mcg · 2x/day · sub-Q
24 posts
Tried AOD locally around a meniscus tear alongside BPC. Subjective improvement, hard to attribute specifically. Encouraged by your report.
212 posts
The change-my-mind posts are the best genre in this forum. Thanks for modeling it.
- CJC-1295 no DAC · 100 mcg · pre-bed · sub-Q
- Ipamorelin · 200 mcg · pre-bed · sub-Q
- BPC-157 · 500 mcg · 2x/day · sub-Q
71 posts
The Metabolic Pharmaceuticals patent literature on AOD-9604 for cartilage/OA is where this use case comes from. It's thin but directionally consistent with the emerging clinical work.
34 posts
Even as a skeptic this kind of update moves me. 'I was wrong about a narrower claim than I thought' is the most useful correction.
52 posts
Adding AOD locally to my rehab toolkit for AC joint and low-grade cartilage issues. Will report back.
- BPC-157 · 250 mcg · 2x/day local · sub-Q
- TB-500 · 2 mg · weekly · sub-Q
73 posts
The standard-issue AOD fat-loss claim is still marketing-grade nonsense. The niche joint use is different. Good clarity.
- BPC-157 · 500 mcg · 2x/day · sub-Q
- GHK-Cu · 2 mg · nightly topical · topical
50 posts
47 posts
Yeah the cartilage literature is actually pretty interesting if you dig past the fat loss noise. The GH secretagogue angle on chondrocyte proliferation shows up in a few papers, though most are in vitro or animal models so grain of salt. Four weeks is a short window but AC joint stuff can move fast if you hit it right. Did you run it systemically or just local injection around the joint?
- Semax · 600 mcg · AM intranasal · intranasal
- Selank · 250 mcg · as needed · intranasal