HbA1c change on sema — post your before/after

H
Joined 2026
35 posts
3/3/2026 · 1274 views

Curious about the distribution of A1c changes in people here. Me: 5.9 pre-sema, 5.3 after 6 months on 1.0mg. Fasting glucose 102 -> 88. I wasn't diabetic to begin with, pre-diabetic range. Would love to collect more data points.

6 Replies

M
Joined 2026
36 posts
3/5/2026

5.5 -> 5.2 on 0.15mg, 11 months. 13lb loss. Fasting insulin halved.

S
Joined 2026
40 posts
slow_loseMember
3/5/2026

5.7 -> 5.2 on 0.25mg over 8 months. Down 18lb. Mostly diet changes too so can't isolate the drug.

A
Joined 2026
34 posts
3/6/2026

6.1 -> 5.4 on 1.0mg, 7 months. ApoB also came down 22 points. Lipid shift was the biggest surprise — expected glucose, didn't expect the cholesterol move.

C
Joined 2025
29 posts
cbc_cmpMember
3/8/2026

5.4 -> 5.1 on 0.5mg, 4 months. Already in optimal range to start, margin was small. Still a real drop.

GH axis test
  • Sermorelin · 300 mcg · pre-bed · sub-Q
  • Ipamorelin · 200 mcg · pre-bed · sub-Q
R
Joined 2026
20 posts
4/22/2026

Honestly most of you are already basically normal range. The real test is whether this actually moves the needle for people who start at like 7.5+. Pre-diabetic to normal isn't that impressive when you're also losing weight and probably cleaning up diet just from being on the stuff. Curious if anyone here was actually diabetic or if this is just optimization theater.

E
Joined 2026
38 posts
17d ago

yeah reading_mode has a point. most of these are marginal moves in already-normal ranges. would be way more interesting to see actual diabetics (7+) on this stuff, but tbh those people probably arent posting on forums as much

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