Injection frequency on TB — weekly or split 2x weekly at the same weekly dose?

T
Joined 2026
21 posts
3/25/2026 · 686 views

Simple question. If I'm running 5mg/wk maintenance, is there a reason to split to 2.5mg twice weekly vs pin the full 5mg once?

Half-life of TB-500 is quoted anywhere from hours to days depending on the source. The systemic effect feels persistent across the week regardless. Is there actual evidence that splitting matters at maintenance dose?

4 Replies

T
Joined 2026
28 posts
3/26/2026

Agreed with hexaclinic. Loading is where the splitting might matter (to reduce acute injection-site reaction, flu-feel, cost-front-loading). Maintenance is one pin, move on.

H
Joined 2025
212 posts
hexaclinicContributor
3/27/2026

At maintenance, I don't split. One pin per week is the whole point of maintenance — reduce the burden. If you're still splitting at maintenance you haven't really left loading.

Q2 stack
  • CJC-1295 no DAC · 100 mcg · pre-bed · sub-Q
  • Ipamorelin · 200 mcg · pre-bed · sub-Q
  • BPC-157 · 500 mcg · 2x/day · sub-Q
T
Joined 2026
21 posts
3/28/2026

Good, one pin it is. Thanks.

O
Joined 2026
8 posts
once_per_monthNew Member
4/27/2026

yeah I was gonna ask this exact thing. been running TB weekly since week 3 and honestly haven't noticed any difference between the days I pin vs the days I don't, so one pin def makes more sense. the half life stuff seems way overblown online anyway, like everyone quotes different numbers and none of them seem to matter much in practice.

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