2.5mg tirze as maintenance after goal weight — anyone running this long term?
21 posts
Hit goal weight at 165lb (from 214). Currently at 10mg. Plan is to step down to 5, then maintenance at 2.5mg indefinitely rather than come fully off. Logic: 2.5 is below the therapeutic weight-loss threshold but still delivers meaningful appetite suppression and metabolic benefit. Should prevent rebound without any of the fast-loss dynamics.
Anyone actually running 2.5 as indefinite maintenance? How long?
7 Replies
29 posts
2.5 maintenance, 18 months. Weight stable within 3lb. Side effects basically zero. Monthly cost reasonable. Best decision I made was not trying to come off fully.
36 posts
Running 2mg tirze weekly (lower than 2.5) for similar reasons. Maintenance is easier at below-therapeutic dose because you're not trying to suppress appetite aggressively — you're just keeping the metabolic signal on.
40 posts
The 'maintenance microdose' approach is increasingly discussed among providers. Not label, but plausible mechanism, and avoids the STEP-4 / SURMOUNT-4 style rebound that occurred in cohorts that came fully off. The counterargument is indefinite drug exposure — long-term safety on chronic low-dose is still being established.
21 posts
Stacking 2.5 tirze with microdose cagrilintide (0.5mg weekly) for maintenance has been my setup for 8 months. The amylin component further smooths satiety. If you're going to stay on something indefinitely, might as well pick a clean dual-agonist approach.
117 posts
No long-term data on chronic low-dose GLP-1/GIP exposure beyond ~5 years. Everyone running indefinite maintenance is in post-trial territory. The choice is reasonable, just state it as 'less data here than active-phase dosing.'
122 posts
The real question is what you're optimizing for. If lifetime weight regulation and the drug has a favorable safety profile at low dose, indefinite maintenance may be appropriate. If you're philosophically committed to 'off all drugs' as an endpoint, you'll need to build a behavioral protocol that replaces what the drug was doing — and that's a bigger project than most people bargain for.
22 posts
Yeah I'm looking at this same path basically. Hit my goal a few months ago and honestly the idea of dropping completely off and watching the weight creep back terrifies me more than staying on a tiny dose forever. The dr_doubt take hits different tho, like if I'm not gonna do the work to keep it off naturally then I'm just deferring the problem. But also I've tried the willpower thing before and it didn't stick so idk, maybe maintenance at 2.5 is just being realistic about what actually works for my brain.