2.5mg tirze as maintenance after goal weight — anyone running this long term?
16 posts
Hit goal weight at 165lb (from 214). Currently at 10mg. Plan is to step down to 5, then maintenance at 2.5mg indefinitely rather than come fully off. Logic: 2.5 is below the therapeutic weight-loss threshold but still delivers meaningful appetite suppression and metabolic benefit. Should prevent rebound without any of the fast-loss dynamics.
Anyone actually running 2.5 as indefinite maintenance? How long?
6 Replies
25 posts
2.5 maintenance, 18 months. Weight stable within 3lb. Side effects basically zero. Monthly cost reasonable. Best decision I made was not trying to come off fully.
29 posts
Running 2mg tirze weekly (lower than 2.5) for similar reasons. Maintenance is easier at below-therapeutic dose because you're not trying to suppress appetite aggressively — you're just keeping the metabolic signal on.
32 posts
The 'maintenance microdose' approach is increasingly discussed among providers. Not label, but plausible mechanism, and avoids the STEP-4 / SURMOUNT-4 style rebound that occurred in cohorts that came fully off. The counterargument is indefinite drug exposure — long-term safety on chronic low-dose is still being established.
115 posts
No long-term data on chronic low-dose GLP-1/GIP exposure beyond ~5 years. Everyone running indefinite maintenance is in post-trial territory. The choice is reasonable, just state it as 'less data here than active-phase dosing.'
119 posts
The real question is what you're optimizing for. If lifetime weight regulation and the drug has a favorable safety profile at low dose, indefinite maintenance may be appropriate. If you're philosophically committed to 'off all drugs' as an endpoint, you'll need to build a behavioral protocol that replaces what the drug was doing — and that's a bigger project than most people bargain for.