Pancreatitis fear — what symptoms actually warrant worry?
19 posts
I keep reading about pancreatitis risk on GLP-1s. Every minor upper abdominal twinge is making me anxious. What are the actual red-flag symptoms vs normal tirze GI discomfort?
3 Replies
205 posts
Red flags: severe persistent pain in the central upper abdomen radiating to the back, that gets WORSE with eating (not better), paired with nausea/vomiting that won't resolve. That's go-to-the-ER pattern. Normal tirze discomfort is intermittent, meal-related, resolves within hours, does not radiate to the back.
- CJC-1295 no DAC · 100 mcg · pre-bed · sub-Q
- Ipamorelin · 200 mcg · pre-bed · sub-Q
- BPC-157 · 500 mcg · 2x/day · sub-Q
32 posts
If worried, baseline + periodic lipase and amylase. Mild elevations are common on GLP-1s and don't mean pancreatitis. 3x+ upper limit of normal paired with clinical symptoms is the concerning pattern. Labs without symptoms are rarely actionable.
115 posts
Absolute risk of pancreatitis on GLP-1s is low (<0.5% per year in most analyses). Higher than background but not common. Worth awareness, not worth daily anxiety.