Do peptides break a fast?
22 posts
Trying to stick to 16:8. If I inject BPC in the morning before breaking my fast, am I defeating the point? The vial is basically nothing calorically right? But insulin response?
7 Replies
31 posts
Different story for GLP-1s (tirz, sema) — those directly affect insulin and glucose. But "breaking a fast" with them isn't really a meaningful concern because the entire point is metabolic signaling. Fasting logic doesn't really apply.
205 posts
Caloric load from a 250mcg BPC dose is effectively zero. Insulin response from a small peptide that isn't a GLP-1/insulin analog is minimal to none. You're fine, BPC doesn't break your fast in any meaningful way.
- CJC-1295 no DAC · 100 mcg · pre-bed · sub-Q
- Ipamorelin · 200 mcg · pre-bed · sub-Q
- BPC-157 · 500 mcg · 2x/day · sub-Q
36 posts
GH secretagogues (ipamorelin, CJC, tesamorelin) are a hot debate for fasting. Some people say the ghrelin agonism "breaks" a fast in a hormonal sense. Most agree it doesn't break it in the autophagy/metabolic sense. But if you're doing an mTOR-off fast for longevity reasons, a GHRH/ghrelin pulse is going the opposite direction.
22 posts
22 posts
31 posts
As always: define the goal of your fast. For 16:8 body comp, peptides are basically irrelevant to the fast. For a deep autophagy fast, different conversation.
16 posts
Interesting question: worth noting most of the "breaks a fast" arguments online are pop-physiology with very thin primary sources. Strict calorie definition is ~0. Hormonal definition is squishy and depends who you ask.