Am I reading this cortisol wrong?

R
Joined 2026
16 posts
22d ago ยท 925 views

AM fasted cortisol came back 22.4 mcg/dL. Lab ref 4.3-22.4. So literally at the top of the range.

I'm running ipamorelin 300mcg bid for 10 weeks. No sleep issues, no anxiety spikes. But 22.4 right at the ceiling is a little worrying. Is this the ipa?

4 Replies

R
Joined 2026
16 posts
21d ago

6:45am. So that's probably most of it.

C
Joined 2025
27 posts
cbc_cmpMember
21d ago

Ipamorelin is specifically designed to NOT bump cortisol โ€” that's its whole selling point vs GHRP-6 and hexarelin. A reading at the top of the reference range on ipa is almost certainly NOT the drug.

What time exactly was the draw? AM cortisol peaks 6-8am. A 6:30am draw will run 25-40% higher than an 8:30am draw.

โ””GH axis test
  • Sermorelin ยท 300 mcg ยท pre-bed ยท sub-Q
  • Ipamorelin ยท 200 mcg ยท pre-bed ยท sub-Q
D
Joined 2025
119 posts
dr_doubtRegular
20d ago

Yeah. Cortisol CV is also ~10-15% on top of the diurnal variation. A 22.4 at 6:45am is basically 'normal healthy person who woke up on time'.

R
Joined 2026
16 posts
20d ago

Okay, panic averted. Thanks.

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