5-Amino-1MQ — NNMT inhibition, dose, and what actually happened

150 mg is on the lower end of what people describe as effective. The 250-300 mg range shows up more often in the positive writeups. Whether that's a real dose-response or selection bias I genuinely don't know.

The NNMT inhibition story is well-supported mechanistically. The human-scale effect in healthy adults has basically no published data. In the rodent work the phenotype in obese models is clearer than in lean models, which might explain why your labs moved less than the marketing suggests.

Ran 300 mg/day for 8 weeks alongside MOTS-c. Can't isolate which was doing what, but subjectively the 5-Amino window felt 'metabolically on' — more energy during fasted training, faster recovery from HIIT.

The 'fat loss peptide' framing in vendor marketing is ahead of the evidence. In obese rodents, yes. In lean humans, mostly no data. Don't expect dramatic body comp results at any dose if your starting phenotype isn't metabolically compromised.

ApoB didn't move for me on 250 mg x 8 weeks either. The lipid story for 5-Amino is overstated in the bro-science writeups.

Appreciating the reality check. Was going to bump to 300 — might pilot that for a 6-week block and report back.

Before bumping the dose, consider whether your metabolic phenotype is the kind the compound actually targets. If you're already lean and insulin sensitive, you may just not have much room for NNMT inhibition to move things.

yeah this thread is actually making me feel better about not jumping to 300 mg right away. i was planning to do that after reading some of the hype but the metabolic phenotype angle makes sense , im already pretty lean and my bloodwork is solid so maybe 5-amino just isnt the move for me right now. might try it anyway for like 6-8 weeks just to see but im not expecting to look dramatically different or anything