Longevity & Khavinson
Epithalon, Rapamycin, FOXO4-DRI.
FOXO4-DRI — senolytic peptide, is anyone trialing?
FOXO4-DRI is the senolytic peptide that got attention after the 2017 Baar et al paper. Disrupts the FOXO4-p53 interaction, allegedly inducing apoptosis preferentially in senescent cells. Is anyone act
Biological age testing on peptides — Elysium vs TruDiagnostic
If I'm running longevity peptides and want to track biological age, which assay is actually worth the money? TruDiagnostic (DunedinPACE), Elysium Index, the myDNAge ones?
SS-31 / Elamipretide — mitochondrial targeting, anyone running it?
SS-31 (elamipretide) binds cardiolipin in the inner mitochondrial membrane and stabilizes electron transport. The clinical trials (primary mitochondrial myopathy, heart failure) have been mixed but me
Rapamycin + peptides — rapa isn't a peptide but it keeps coming up
Rapamycin (sirolimus) is the pharma longevity compound that actually has rodent data behind it. It's not a peptide. But every longevity peptide conversation eventually drags it in. Anyone running rapa
Khavinson bioregulators — Pinealon, Cortexin, and the short-peptide theory
Khavinson developed a whole family of short peptide bioregulators beyond Epithalon — Pinealon (3 aa), Cortexin (polypeptide extract), Cerluten, etc. Each is theoretically tissue-specific (pineal, cort
Humanin — mitochondrial peptide, is anyone running it?
Humanin is another mitochondrial-derived peptide (encoded within the 16S rRNA gene). Has anti-apoptotic and metabolic effects in preclinical work. Unlike MOTS-c it hasn't really caught on in the commu
NAD+ precursors (NR / NMN) alongside peptides
NR and NMN are oral NAD+ boosters that get stacked with longevity peptides routinely. Is there a reason to run them together, or is it mostly habit + marketing? And does anyone actually see NAD+ level
Epithalon — Khavinson's original 10mg x 10 days protocol, three cycles in, writing it up
Been running Khavinson's classical Epithalon protocol — 10 mg/day SubQ for 10 days, then 80 days off — for three cycles now (so ~10 months elapsed). Writing this up because the space is split between
5-Amino-1MQ — NNMT inhibition, dose, and what actually happened
5-Amino-1MQ is an NNMT inhibitor (nicotinamide N-methyltransferase). In theory inhibiting NNMT should spare SAM and NAD+ precursors and improve metabolic phenotype in adipose. Ran 150 mg/day oral, 12
Epithalon — alternate protocols (daily low dose vs classical 10/80)
Some people run 2-5 mg daily for 30 days instead of 10 mg for 10 days. Pharmacokinetically they're very different — daily low dose is a sustained exposure, 10/80 is a pulsatile course. Khavinson's or
MOTS-c — a year of dosing, metabolic labs, and what I actually think is happening
Year of MOTS-c in the books. Posting because the writeups on this compound are mostly 'felt great' with no numbers, and the skeptic takes are mostly 'no human data' without engaging with what the huma
Telomere testing — is it actually worth tracking?
Considering Life Length or TeloYears or similar as a way to track longevity interventions. But the literature on telomere length variability and measurement noise is not encouraging. Is there any vers