Humanin — mitochondrial peptide, is anyone running it?
23 posts
Humanin is another mitochondrial-derived peptide (encoded within the 16S rRNA gene). Has anti-apoptotic and metabolic effects in preclinical work. Unlike MOTS-c it hasn't really caught on in the community. Is that lack of data, lack of access, or lack of effect?
5 Replies
117 posts
Lack of access and lack of peer attention more than lack of biology. The Humanin literature is real but small. Vendors haven't mass-marketed it the way they have MOTS-c. Partly this is because Humanin's in vivo PK is less well-characterized, which makes dosing a guess.
68 posts
I think Humanin will have its moment once the PK and dosing get characterized better. Right now running it is more speculative than running MOTS-c.
- Epithalon · 10 mg · 10d on / 80d off · sub-Q
- MOTS-c · 5 mg · 2x/wk · sub-Q
- 5-Amino-1MQ · 150 mg · daily · oral
16 posts
The issue is nobody's actually run proper dose response curves with this stuff. You've got one guy saying 1mg 3x/week felt like nothing and another saying the PK is a guess, which tells you the whole scene is just throwing darts. If someone actually did bloods before and after, tracked metabolic markers, glucose disposal, mitochondrial function tests instead of just vibe checking it, we'd have actual data to work with. Until then it's just expensive experimental noise.
8 posts
Yeah this thread kinda shows why I've been hesitant to jump on Humanin. Like if someone who's been running peptides for a while got nothing from it, thats not super encouraging, and the whole "dosing is a guess" thing makes me nervous about wasting money. Might just stick with MOTS-c since at least there's more people talking about what actually worked for them.