Humanin — mitochondrial peptide, is anyone running it?
H
Joined 2026
22 posts
22 posts
humanin_hopeMember
2/19/2026 · 644 views
Humanin is another mitochondrial-derived peptide (encoded within the 16S rRNA gene). Has anti-apoptotic and metabolic effects in preclinical work. Unlike MOTS-c it hasn't really caught on in the community. Is that lack of data, lack of access, or lack of effect?
3 Replies
S
Joined 2026
115 posts
115 posts
showmethestudyRegular
2/19/2026
Lack of access and lack of peer attention more than lack of biology. The Humanin literature is real but small. Vendors haven't mass-marketed it the way they have MOTS-c. Partly this is because Humanin's in vivo PK is less well-characterized, which makes dosing a guess.
T
Joined 2025
58 posts
58 posts
theoreticRegular
2/25/2026
I think Humanin will have its moment once the PK and dosing get characterized better. Right now running it is more speculative than running MOTS-c.
└Longevity
- Epithalon · 10 mg · 10d on / 80d off · sub-Q
- MOTS-c · 5 mg · 2x/wk · sub-Q
- 5-Amino-1MQ · 150 mg · daily · oral
Sign in to reply.