Cold plunges + peptides — stacking the autonomic benefits?
58 posts
Cold exposure is one of the few non-pharmacological tools with solid autonomic/metabolic data. I've been running 3x/week cold plunges (3-5 min, ~45F) for a year. Good HRV signal, good "feeling."
Thinking about how this interacts with peptide cycles:
- MOTS-c and cold — both push mitochondrial biogenesis. Stack or redundant?
- BPC-157 post-cold — anyone time it this way?
- Epithalon and cold — any reason not to?
- Cold stress vs recovery — do peptides change the optimal frequency?
Curious what people have noticed empirically, and whether there's any reason for caution combining.
- Epithalon · 10 mg · 10d on / 80d off · sub-Q
- MOTS-c · 5 mg · 2x/wk · sub-Q
- 5-Amino-1MQ · 150 mg · daily · oral
7 Replies
31 posts
I stopped cold exposure on BPC-157 cycles after a soft-tissue injury. Cold vasoconstriction seemed to slow my perceived recovery. Anecdotal.
- BPC-157 · 500 mcg · 2x/day local to knee · sub-Q
- TB-500 · 5 mg · weekly loading · sub-Q
115 posts
Cold exposure literature is actually stronger than most peptide literature on measurable endpoints. If someone's choosing one intervention, start with cold.
205 posts
Cold post-weight-training blunts hypertrophy. Keep that in mind if muscle building is a goal. Probably matters less if you're not training for growth.
- CJC-1295 no DAC · 100 mcg · pre-bed · sub-Q
- Ipamorelin · 200 mcg · pre-bed · sub-Q
- BPC-157 · 500 mcg · 2x/day · sub-Q
26 posts
My HRV from cold is 2-3ms above baseline rolling. MOTS-c adds another 2-3 on top. They don't seem to cancel, if anything additive.