Thought 5-Amino-1MQ was hype, it's actually doing something
37 posts
Contrarian update. I dismissed 5-Amino-1MQ as another NNMT-inhibitor hype compound for a year. Finally tried it on a friend's insistence.
12 weeks, 100mg oral daily. Maintenance calories. No other changes.
-1.1kg scale weight. DEXA says -0.9kg fat, +0.1kg LBM. Not dramatic, but at maintenance calories with nothing else moved? That's something.
Not changing my mind that the long-term safety data is thin. But I'm updating from "nothing" to "real but uncertain."
5 Replies
115 posts
The mechanism (NNMT inhibition → methyl donor availability → sirtuin activity) is plausible. The long-term safety of chronic NNMT inhibition in humans is the open question. I wouldn't run it continuously.
205 posts
Aggressive cycling (12 on, 12 off) is the conservative play here until there's more data. Don't run it year-round.
- CJC-1295 no DAC · 100 mcg · pre-bed · sub-Q
- Ipamorelin · 200 mcg · pre-bed · sub-Q
- BPC-157 · 500 mcg · 2x/day · sub-Q
37 posts
30 posts
At maintenance calories with -0.9kg DEXA fat over 12 weeks — that is meaningful for a non-pharma agent. Would be curious to see this in someone losing on a deficit as well.