Thought 5-Amino-1MQ was hype, it's actually doing something
43 posts
Contrarian update. I dismissed 5-Amino-1MQ as another NNMT-inhibitor hype compound for a year. Finally tried it on a friend's insistence.
12 weeks, 100mg oral daily. Maintenance calories. No other changes.
-1.1kg scale weight. DEXA says -0.9kg fat, +0.1kg LBM. Not dramatic, but at maintenance calories with nothing else moved? That's something.
Not changing my mind that the long-term safety data is thin. But I'm updating from "nothing" to "real but uncertain."
6 Replies
117 posts
The mechanism (NNMT inhibition → methyl donor availability → sirtuin activity) is plausible. The long-term safety of chronic NNMT inhibition in humans is the open question. I wouldn't run it continuously.
212 posts
Aggressive cycling (12 on, 12 off) is the conservative play here until there's more data. Don't run it year-round.
- CJC-1295 no DAC · 100 mcg · pre-bed · sub-Q
- Ipamorelin · 200 mcg · pre-bed · sub-Q
- BPC-157 · 500 mcg · 2x/day · sub-Q
43 posts
30 posts
At maintenance calories with -0.9kg DEXA fat over 12 weeks — that is meaningful for a non-pharma agent. Would be curious to see this in someone losing on a deficit as well.
34 posts
The DEXA data is what makes this interesting to me. At maintenance, losing fat without gaining LBM is the baseline expectation, not the win. But if 5A1MQ is actually shifting that ratio even slightly in the positive direction, that's mechanistically relevant. The NNMT angle tracks with some of the sirtuin literature but yeah, nobody's actually run this in humans long enough to know if chronic inhibition causes weird downstream issues. I'm curious whether the recomposition effect holds or tanks when you run it again after the 12 off.