PDE inhibitors vs cog peptides for daily work focus

P
Joined 2026
23 posts
17d ago · 385 views

Weighing daily low-dose tadalafil (vascular / generally systemic) vs Semax AM for cognitive work output.

They're obviously different tools. But I'm trying to figure out where to spend the budget if picking one. Anyone used both and formed a preference?

4 Replies

S
Joined 2026
41 posts
15d ago

Different jobs. Tadalafil isn't a focus tool for most people. If cognitive work output is the target, Semax is the more direct choice. If general vascular/recovery is the goal, tadalafil.

Focus stack
  • Semax · 600 mcg · AM intranasal · intranasal
  • Selank · 250 mcg · as needed · intranasal
H
Joined 2025
205 posts
hexaclinicContributor
14d ago

Low-dose tadalafil has a surprising portfolio (prostate, possibly cardiovascular, possibly cognitive via vascular mechanism) but the cognitive effect is indirect. Wouldn't compare head to head with a direct nootropic.

Q2 stack
  • CJC-1295 no DAC · 100 mcg · pre-bed · sub-Q
  • Ipamorelin · 200 mcg · pre-bed · sub-Q
  • BPC-157 · 500 mcg · 2x/day · sub-Q
P
Joined 2026
23 posts
12d ago

Going Semax for the acute cognitive goal. Will reconsider tadalafil for the vascular use case separately. Thanks.

C
Joined 2026
23 posts
10d ago

If budget stretches further a Cerebrolysin course twice yearly might sit on top of daily Semax better than either alone. Different time horizons.

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