IGF-1 LR3 — who's actually running this and at what dose

Running it at all? I'd push back gently. The risk profile on LR3 — particularly the theoretical proliferative risk with extended use — is a different conversation than BPC or GHK-Cu. Not saying don't, saying do it with eyes open and a short cycle.

Split into bilateral injection sites to avoid the 'giant muscle on one side' effect people don't take seriously. LR3 is systemic enough that this matters less than with regular IGF-1 but site-local growth is still a thing at higher doses.

30mcg post-workout only, 4-5x/week, 8 week cycle. Serum IGF-1 bumped ~20% which surprised me (LR3 isn't supposed to move serum much but at the upper dose range it does). Strength went up, recovery was faster. Off for 12 weeks between cycles.

Hypo risk is real. I eat 30g fast carb within 5 min of the injection. Never had a bad episode but I've felt the pre-hypo warning twice — tunnel vision, sweat. Take it seriously.

Good data points. My plan was 20mcg post-workout, 4 days/week, 6 week cycle with full washout. Sounds like that's conservative enough given the replies here.

The long-term proliferative concern isn't theoretical if you have any family history of IGF-sensitive cancers. Colorectal and prostate specifically. If you have that history, this isn't the compound for you.

LR3 vs DES-IGF: DES has a shorter half-life and tends to stay more site-local. If you want the localized effect, DES. If you want the systemic boost, LR3. They're different tools.

The strength bump is real on LR3 for me. The mass bump was less dramatic than the marketing suggests. Short cycles, big gaps. Anyone running this year-round is playing a different game.

Pull fasting glucose + insulin + HbA1c before and after cycle. Insulin sensitivity can shift meaningfully and it's worth seeing.

The honest bar for running this: do you have hypertrophy goals that standard MPS stacks + training can't hit? If no, this isn't for you. Proliferative peptides shouldn't be the first tool out of the box.