Other Compounds
PT-141, DSIP, MOTS-c, etc.
Cerebrolysin — the cost is insane. Is it worth it?
Cerebrolysin is a porcine-brain-derived neuropeptide preparation used in Europe for stroke, TBI, and dementia. In those indications the evidence is... okay. Not great, not nothing. Effect sizes are mo
Kisspeptin-10 for HPTA restart after a long cycle — anyone run this?
Kisspeptin-10 is upstream of GnRH in the HPTA axis. The theoretical appeal for post-cycle recovery is that it kicks the whole cascade off at the top rather than from the pituitary downward (like clomi
IGF-1 LR3 — who's actually running this and at what dose
IGF-1 LR3 is one of those compounds you see mentioned as a 'serious' peptide but almost no one talks honest doses and effects. Half the posts are either 'I'm running 100mcg daily' (unhinged) or 'it di
Dihexa — is anyone actually running this safely
Dihexa keeps coming up in nootropic circles as '7 orders of magnitude more potent than BDNF for synaptic formation.' That's the kind of claim that should make anyone pause. It's also never been in a h
MOTS-c dose debates — 10mg weekly vs 5mg 2x week vs daily microdose
MOTS-c is a mitochondrial-derived peptide with metabolic and exercise-mimetic claims. Protocols vary wildly: - 10mg once a week (the 'pulse' school) - 5mg twice a week (the 'split' school) - 1–2mg da
Thymosin Alpha-1 for chronic immune issues — worth the cost?
Thymosin Alpha-1 (TA-1, Zadaxin) is an immune modulator used in Asia and parts of Europe for hepatitis and as an adjunct for immunocompromised patients. It's expensive and obscure in the US but some p
AOD-9604 — cool name, does it do literally anything?
AOD-9604 is marketed as 'the fat-burning fragment of growth hormone.' The origin story is that it's the C-terminal fragment of hGH (176-191) that supposedly retains the lipolytic effect without the gr
KPV — alpha-MSH fragment for gut inflammation, any experiences?
KPV is a three amino acid fragment of alpha-MSH (lys-pro-val) with anti-inflammatory properties in gut models. Some IBD sufferers are using it oral (enteric coated) or rectal to target local gut infla
Follistatin / FS-344 — is anyone really using this for hypertrophy?
Follistatin gene therapy (AAV-FS344) has been floated in research for muscular dystrophy. The peptide analogs sold in the gray market are different things and the 'follistatin 344' vials out there are
DSIP for sleep — who's actually gotten something out of this
Delta sleep-inducing peptide (DSIP) has been on the fringe of the sleep compound conversation for decades. The human literature is mostly old Russian and European work, and modern trials are basically
Selank vs Semax for anxiety — I've tried both, here's how they're actually different
Tried both Russian nasal peptides for generalized anxiety over the last year. People online tend to lump them together as 'nootropic anxiolytics' but they're very different in practice. **Semax** (AC
5-Amino-1MQ — NNMT inhibitor, anyone running this for recomp?
5-Amino-1MQ is a small molecule NNMT (nicotinamide N-methyltransferase) inhibitor that's been pitched as an adipocyte-targeting 'increase-NAD-available-for-everything-else' tool. Unlike most things on
PT-141 dosing thread — let's compile what actually works vs 'just take 2mg and hope'
PT-141 (bremelanotide) is a melanocortin agonist that hits MC3/MC4 receptors and does something for sexual arousal that Viagra and Cialis don't. But the dose window is narrow, the side effect profile
Epithalon protocol variations — 10 days on / months off vs the longer runs
Canonical epithalon protocol is 10 consecutive days of 5–10mg sub-q, 1-2x per year. This traces back to the Khavinson work out of St. Petersburg. But I see variations now: - 10mg daily for 20 days -