Desensitization — how fast does it actually happen on GHRPs

Subjective marker that's held up: 'morning fasted hunger.' On GHRP the ghrelin-receptor agonism gives a hunger bump post-pin. When desensitization kicks in, that hunger bump fades. I use it as a free crude biomarker.

IGF-1 at week 2, 4, 6, 8 is the single best marker. My typical curve: week 2 +40, week 4 +70 (peak), week 6 +68, week 8 +55. The peak at 4 and decline by 6 is what desensitization looks like in blood.

Sleep depth via wearable is a reasonable proxy. First 2 weeks of Ipa pre-bed my deep sleep spikes. Week 4 it normalizes. Week 6 it's below baseline. The curve is reproducible across cycles.

5-on/2-off has held up for me across 6+ cycles of longer duration. Not proof but the subjective-and-wearable curve is flatter than on straight 7 days/wk. Feels like it extends the useful window to ~10-12 weeks.

The GH secretagogue receptor downregulation timeline in humans is not well characterized. Most of what we 'know' comes from a handful of studies in GH deficiency patients plus anecdotal forum reports. Be careful about precise claims.

Compound rotation mid-cycle is a real strategy. I know vets running ipa weeks 1-3, hexarelin weeks 4-5, GHRP-6 weeks 6-8. Each one hits a slightly different receptor avidity profile, extending total window. Not for beginners.

Dose escalation to 'push through' desensitization is the worst of the options. You get mild extension and harder sides. Cycle off wins.

The 3-4 week recovery number I'd quibble with slightly. For Ipa that holds. For hexarelin, sensitivity recovery is more like 5-6 weeks in my experience.

Great data points. Consolidating: IGF-1 at 2/4/6/8, subjective hunger pulse post-pin, wearable deep sleep trend. Three cheap markers, probably sufficient. Compound rotation is next-level but real.

Saving. This thread is the best summary of desensitization markers I've read.

Would love a community-assembled dataset of IGF curves across cycles. Could probably identify responder archetypes.