Stack for chronic tendinopathy — BPC is working but slow, what do I add

J
Joined 2026
27 posts
3/6/2026 · 2894 views

Chronic medial epicondylitis, 14 months. Tried PT, rest, eccentrics, PRP injection. Marginal. Started BPC-157 6 weeks ago (250mcg local, 2x weekly) and 250mcg Sub-Q daily. Pain 6/10 → 3/10 at week 6. Moving but slower than I'd hoped.

Considering adding:

  • TB-500 5mg weekly
  • GHK-Cu local
  • CJC/Ipa systemic for collagen synthesis support

Which is the highest-yield add? Or am I being impatient and should give BPC another 4 weeks?

9 Replies

T
Joined 2025
50 posts
3/7/2026

Chronic tendinopathy is slow. 6 weeks on BPC with 3-point reduction is actually a good trajectory. I'd give it 4 more weeks before stacking. That said, TB-500 is the single best systemic add for chronic tendon pathology in my experience.

Pulley A2
  • BPC-157 · 250 mcg · 2x/day local · sub-Q
  • TB-500 · 2 mg · weekly · sub-Q
S
Joined 2026
14 posts
3/8/2026

CJC/Ipa adds collagen synthesis support via IGF. For chronic tendinopathy where you're rebuilding tissue, it's synergistic. Not a fast fix but compounds the BPC work.

R
Joined 2026
31 posts
3/8/2026

GHK-Cu locally is pleasant but the tendon evidence is thinner than BPC/TB. I'd put it last in your priority list.

S
Joined 2025
94 posts
3/8/2026

The eccentric loading is the real driver, peptides are potentiators. Are you still doing Tyler twist or the Alfredson protocol daily? If rehab went on pause while BPC started, THAT'S your yield.

Growth + recovery
  • CJC-1295 no DAC · 100 mcg · pre-bed · sub-Q
  • Ipamorelin · 200 mcg · pre-bed · sub-Q
  • BPC-157 · 250 mcg · 2x/day · sub-Q
J
Joined 2026
27 posts
3/9/2026

@stackbuilder doing tyler twist 2x/day daily. Hadn't paused. That's real though — I should make sure rehab volume is full before adding compounds.

H
Joined 2025
205 posts
hexaclinicContributor
3/9/2026

Medial epi specifically: make sure your wrist flexor stretching is consistent, not just eccentrics. Passive flexibility work is under-rated. Peptides + load + range. All three.

Q2 stack
  • CJC-1295 no DAC · 100 mcg · pre-bed · sub-Q
  • Ipamorelin · 200 mcg · pre-bed · sub-Q
  • BPC-157 · 500 mcg · 2x/day · sub-Q
M
Joined 2026
14 posts
3/10/2026

TB-500 for 4 weeks at 5mg loading changed the chronic ache pattern for me on an old elbow issue. Felt different from BPC — more systemic 'quieting' of the area.

D
Joined 2025
119 posts
dr_doubtRegular
3/11/2026

If pain went from 6 to 3 in 6 weeks on BPC alone, you're not plateaued. Wait 4 more weeks, re-evaluate. Don't stack on a moving target — you lose the attribution.

J
Joined 2026
27 posts
3/12/2026

Okay, consensus seems to be: hold, keep rehab tight, re-evaluate at week 10. If still stuck, add TB-500 next. Thanks all.

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