5-on/2-off weekly pulsing — does this actually extend a GHRP cycle

I ran 8 weeks 7/7 followed by 8 weeks 5/2 the next cycle. 7/7: IGF peaked at week 4 at 284, fell to 240 by week 8. 5/2: peaked week 5 at 276, held at 254 at week 8. Directionally consistent with your hypothesis but differences within noise.

Sleep marker: on 7/7 my deep sleep starts declining around week 5. On 5/2 it holds better through week 6-7. Crude n=1 but reproducible across two cycles each.

5/2 is a reasonable heuristic but doesn't change the 8-week cap for me. It smooths the decay, doesn't extend the peak. If the goal is 'longer useful cycle,' compound rotation works better.

The receptor resensitization literature for GHSR specifically is thin. The 'brief rest = partial recovery' hypothesis is plausible from general GPCR dynamics but not proven for this receptor. Treat the heuristic as reasonable, not established.

Variability between cycles within one person is on the same order as the 7/7 vs 5/2 effect. To really answer this you'd need a within-subject crossover with matched baseline. Hard to do as a hobbyist.

Practical value of 5/2: gives you two weekend 'pin off' days which helps with lifestyle adherence. Independent of the biology, that matters.

Fair. Summary: 5/2 has marginal biology benefit, real adherence benefit, doesn't replace periodic cycling off. Using that as my default going forward.

5/2 weekly + 8/4 cycling is a reasonable belt-and-suspenders approach. Adherence + biology.

Saving this. Clean discussion with realistic caveats.