Sleep stack — MOTS-c + epitalon + pre-bed GH sec, real or overkill

D
Joined 2026
18 posts
dreamlineMember
3/1/2026 · 2655 views

Running this for 8 weeks to see if I can push sleep metrics. Stack:

  • MOTS-c 10mg weekly Sub-Q (started week 1)
  • Epitalon 10mg daily for 10 days (weeks 5-6)
  • CJC no-DAC 100 + Ipa 150 pre-bed (weeks 1-8)

Baseline Oura: deep 68min avg, REM 94min, HRV 42. Week 4 Oura: deep 84min, REM 112min, HRV 51.

Is the improvement from the GH sec alone, the epitalon (though it hadn't started yet), the MOTS-c systemic effect, or placebo? Trying to pull this apart.

9 Replies

E
Joined 2026
36 posts
3/2/2026

Run epitalon weeks 5-6 as planned, re-measure week 6-7. If deep/REM go up further or HRV climbs, attribute to epi. If flat, the GH sec is doing the work.

R
Joined 2026
32 posts
restwiseMember
3/3/2026

Week 4 gains are entirely the CJC/Ipa window. Epitalon wasn't started, MOTS-c systemic sleep effect is marginal. The deep sleep bump from Ipa pre-bed is the best-known sleep pharmacology in the stack.

M
Joined 2026
32 posts
motsc_opsMember
3/3/2026

MOTS-c's sleep effect in my data is modest and slow — 4+ weeks before any subjective shift. At week 4 you wouldn't expect much from MOTS-c alone.

C
Joined 2026
71 posts
3/4/2026

GH sec pre-bed + sleep metrics is well-established. Epitalon sleep effect is supported by Russian literature but not well-replicated elsewhere. MOTS-c sleep is speculative. Your attribution order should follow the evidence weight.

D
Joined 2026
18 posts
dreamlineMember
3/5/2026

Good. Will hold the CJC/Ipa doses constant and let the epitalon block isolate. Will report week 6 vs week 4.

P
Joined 2025
71 posts
3/6/2026

You're doing this the right way. Isolate the variable (epi) by running it in a window and comparing. Most people would add everything at once and never learn what's doing what.

Healing + skin
  • BPC-157 · 500 mcg · 2x/day · sub-Q
  • GHK-Cu · 2 mg · nightly topical · topical
N
Joined 2026
31 posts
3/7/2026

NAD+ 100mg Sub-Q 2hr pre-bed is another sleep-active compound I'd rotate in eventually. Deep sleep bumps in my data. Consider for a subsequent cycle.

H
Joined 2026
22 posts
3/9/2026

The mitochondrial class (MOTS-c, humanin, NAD+) collectively seems to shift sleep architecture over months not weeks. Sleep is one of the downstream markers that moves last, in my experience.

D
Joined 2026
18 posts
dreamlineMember
3/15/2026

Week 6 update for anyone following: deep 87min (up 3 from week 4), REM 118 (up 6), HRV 53 (up 2). Epitalon block is contributing but small relative to the CJC/Ipa baseline. Solid addition, not transformative.

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