Loading phase on BPC-157 — 2 weeks at 500mcg worth it
10 posts
Conventional dose for BPC is 250-500mcg daily. Question I keep running into: does a 2-week loading phase at 500mcg bid (total 1mg/day) during the acute phase of an injury give meaningfully faster onset vs running 250mcg daily from the start?
My sense: yes for acute soft tissue, marginal for chronic tendinopathy. Anyone have side-by-side experience?
8 Replies
31 posts
Loaded BPC at 500 bid for 2 weeks post-MCL sprain. Pain curve was steeper than my prior MCL without loading. Hard to control for severity though.
50 posts
For acute soft tissue (sprain, partial tear, bruise with hematoma), loading phase at 500 bid is worth it. The tissue is in an active repair window and higher dose seems to compress timeline. For chronic, the tissue response is rate-limited by other factors.
- BPC-157 · 250 mcg · 2x/day local · sub-Q
- TB-500 · 2 mg · weekly · sub-Q
205 posts
No strong data either way. My rule of thumb: load for 10-14 days on acute injuries, then drop to maintenance 250-500 once daily. Prevents running hot doses for weeks unnecessarily.
- CJC-1295 no DAC · 100 mcg · pre-bed · sub-Q
- Ipamorelin · 200 mcg · pre-bed · sub-Q
- BPC-157 · 500 mcg · 2x/day · sub-Q
94 posts
The cost of loading is mild — BPC tolerance at 1mg/day is fine for most. Downside is burning through your supply faster. For chronic stuff, I wouldn't bother.
- CJC-1295 no DAC · 100 mcg · pre-bed · sub-Q
- Ipamorelin · 200 mcg · pre-bed · sub-Q
- BPC-157 · 250 mcg · 2x/day · sub-Q
71 posts
The rodent literature supports dose-response up to about 400mcg/kg (equivalent scaled to 30mcg/kg in humans, ~2mg for a 70kg adult). Beyond that, plateau. So loading at 1mg/day is well within the dose-response curve.
10 posts
Consolidating: load for acute, maintain for chronic. Dose response plateau around 2mg/day in humans. Makes sense.
27 posts
Good thread. Changing my protocol for next acute injury to include 2 weeks at 500 bid.
25 posts