Side effects at 10mg — HR, nausea, and what's normal vs what's a flag

HR up 9 and BP up 8/8 is the GCG arm doing what it does. Not alarming in isolation, but if the trend continues past week 14 or you hit 130/85 sustained, back off to 8mg. The CV stuff creeps and then isn't reversible in the same timeframe.

Mood flattening on incretin class is underdiscussed. Hedonic response tanks for some people, probably dopaminergic downregulation secondary to reduced food reward. Usually partially rebounds 2-3 weeks after stopping or dropping dose.

Match all of this except I'm not getting the flat mood. Curious if it's baseline-dependent — I was running kind of hypomanic pre-reta so a damped mood feels like normal to me.

Log your HR trend weekly going forward. The inflection point is what matters, not the absolute. If HR is still climbing at week 14, that's different from plateauing at 67.

@dr_doubt this is a real reframe. I've been treating the weight loss as the only metric. Adding a weekly subjective wellness score to my log starting today.

The 'muted' mood report is the subtle side effect that makes people quit reta after they've already lost a lot of weight. Name it so you can track it. If at week 20 you're 40lb down and still feel emotionally dim, weight loss is not making you happier.

Sleep decline matches what I'd expect — GCG arm runs you warmer and that compromises deep sleep. Not a flag, but if it persists past adaptation (4-6 weeks at dose), consider dropping back.

This thread is the kind of honest side effect log I needed before starting. Most 'my reta journey' posts pretend everything is fine.

HR creep is dose-dependent and usually stabilizes, but 9bpm in 2 weeks is moving faster than I'd like to see. Get fasted resting HR for 3-4 days straight instead of spot-checking it, that'll tell you if it's actually climbing or just noise. BP up 8/8 though, that's worth noting. The mood flattening is real and nobody talks about it because it happens slow, but if you're serious about this you need actual bloodwork at week 12 or 13, not just vibes. Lipids, fasting glucose, and a full metabolic panel. That's the only way to know if the cardio changes are adaptation or if something's actually shifting in ways that matter.