Retatrutide
Triple agonist.
Phase 3 timeline speculation — when does reta actually hit market
Lilly's SURPASS-style trials for reta (TRIUMPH program) have readouts rolling through 2025-2026. Primary obesity endpoint trial (TRIUMPH-4) was supposed to wrap this spring. Based on the tirze timeli
Reta vs tirze — 16 weeks in, the efficacy jump is not subtle
Ran tirze 2.5 → 10mg over 20 weeks last year. Lost 28lb, plateaued hard at 10mg, couldn't push further without brutal GI. Swapped to retatrutide 8 weeks ago after a 3-week washout. Stats: 38M, starte
Titration debate — 2/4/8/12 vs slow crawl
Seeing a split in the reta community on titration aggression. The 'Lilly schedule' from trial data is basically 2mg for 4 weeks, 4mg for 4, 8mg for 4, then 12mg. That's the safe lane. But the researc
Reta for metabolic syndrome — off-label use case
46M, T2D marginal (HbA1c 6.2), visceral fat problem (waist 41"), lipids disaster (triglycerides 240, ApoB 128). Not obese by BMI (27). Endocrinologist is hesitant on GLP-1 because I'm not technically
First reta cycle checklist — am I missing anything
Starting in 2 weeks. Here's my plan: - Baseline bloods drawn this week (CBC, CMP, lipids, A1c, fasting insulin, lipase/amylase, thyroid, cortisol AM). - Starting dose 2mg Sunday AM, titrate every 4 we
Training on 10mg — is it realistic
Started reta 9 weeks ago. Training intensity is noticeably down at 8mg, worried 10mg will end my lifting window. Lifting 4x/week, mid-to-high volume, avg 75 min sessions. At 8mg I'm hitting sessions
Sourcing reta — what does the market look like right now
Not asking for vendors. Asking about market conditions — has reta supply stabilized in the research chem channel? Six months ago every batch was a guessing game. Has HPLC availability caught up?
Side effects at 10mg — HR, nausea, and what's normal vs what's a flag
Week 11, been on 10mg for 2 weeks. Logging what I'm feeling so others can calibrate. - Resting HR: baseline 58, currently 67. Up 9bpm from baseline, up 4 from the 8mg plateau. - Nausea: 2/10 backgrou
Switching from tirze — 3 week washout or bridge?
Running tirze 7.5mg currently. Want to swap to reta in the next month. Question: do I just stop tirze, wait, and start reta? Or is there a bridging protocol? Half-life of tirze is ~5 days so at ~3 we
Why three receptors matters — GCG arm for lipolysis, not just weight
People talk about reta as 'tirze plus.' It's not. The glucagon receptor agonism does something tirze literally cannot do — direct lipolysis and increased resting energy expenditure. Mechanism in brie