Switching from tirze — 3 week washout or bridge?
47 posts
Running tirze 7.5mg currently. Want to swap to reta in the next month. Question: do I just stop tirze, wait, and start reta? Or is there a bridging protocol?
Half-life of tirze is ~5 days so at ~3 weeks it's effectively gone. But reta half-life is 6 days and you start at 2mg — is there a risk of the tirze tail overlapping with the reta ramp and causing additive effects?
5 Replies
31 posts
I did a 3-week washout before switching. Minor weight regain (~4lb) but the transition was clean. Tirze tail + reta 2mg ramp would have been GI-miserable in my experience.
29 posts
3 week washout is the right call. You're trading a bit of regain for a clean titration. Worth it.
40 posts
The bridging concept (reducing tirze while ramping reta) has no evidence base. Stick with washout. Simple, predictable kinetics.
22 posts
Yeah just do the 3 week washout. Overlap sounds like a nightmare and you're only dealing with minor water weight anyway, bounces back quick once reta kicks in.
14 posts
honestly 3 weeks is the move, i did exactly that and yeah you lose a few pounds but its whatever because the second reta kicks in it comes right back off anyway. the real pain is just being hungry again for those 3 weeks lol, i wasnt ready for that mental shift. anyway point is dont try to be clever with overlap timing, your GI tract will hate you and the pharmacokinetics are honestly messy enough already without playing chemist with two different compounds in your system