Reta for metabolic syndrome — off-label use case
31 posts
46M, T2D marginal (HbA1c 6.2), visceral fat problem (waist 41"), lipids disaster (triglycerides 240, ApoB 128). Not obese by BMI (27). Endocrinologist is hesitant on GLP-1 because I'm not technically diabetic and 'just' overweight.
Reta's metabolic profile — the GCG arm especially — looks ideal for this picture. Visceral fat, triglycerides, hepatic steatosis.
Anyone running reta for metabolic syndrome specifically (not primarily for weight)? What dose range, what markers moved first?
4 Replies
33 posts
Not on reta but on tirze for similar reasons (A1c 5.9, viceral AT, trigs 210). 4 months in: trigs 98, ApoB 78, A1c 5.4, waist -3.5". I'd expect reta to hit harder on trigs specifically because GCG-driven hepatic fat clearance.
31 posts
Plan: 2mg x 4, 4mg x 6 weeks, draw full panel week 10. If trigs below 150 and ApoB below 100 I'd consider that success at 4mg and hold.
205 posts
Metabolic syndrome is arguably reta's best indication given the three-receptor profile. Hepatic fat in particular responds fast. I'd expect trigs and liver enzymes to move inside 6 weeks at 4mg.
- CJC-1295 no DAC · 100 mcg · pre-bed · sub-Q
- Ipamorelin · 200 mcg · pre-bed · sub-Q
- BPC-157 · 500 mcg · 2x/day · sub-Q