Chronic tendinopathy that hasn't responded to anything — TB alone or stack?

T
Joined 2025
52 posts
4/1/2026 · 821 views

5 years of left patellar tendinopathy. Tried everything short of PRP and surgery: rehab (multiple cycles, eccentric protocols done properly), PT for months, dry needling, shockwave, BPC cycles (3 of them). All gave partial relief that didn't stick.

Considering a full TB-500 cycle alone to see if the systemic angle unlocks something BPC hasn't. Or I should stack with BPC again despite diminishing returns?

Partial response to BPC — not nothing, not a fix. Curious if people with similar 'BPC didn't finish the job' cases found TB did anything additional.

Pulley A2
  • BPC-157 · 250 mcg · 2x/day local · sub-Q
  • TB-500 · 2 mg · weekly · sub-Q

6 Replies

H
Joined 2025
212 posts
hexaclinicContributor
4/1/2026

Chronic tendinopathy that's had 5 years of peptide and rehab is mechanically different from an acute tendinopathy. The collagen architecture has actually changed — it's disorganized and fibrotic. Peptides are better at acute repair than at reorganizing old scar-like tissue. Worth considering whether you're chasing the wrong tool.

Q2 stack
  • CJC-1295 no DAC · 100 mcg · pre-bed · sub-Q
  • Ipamorelin · 200 mcg · pre-bed · sub-Q
  • BPC-157 · 500 mcg · 2x/day · sub-Q
R
Joined 2026
32 posts
4/2/2026

Chronic rotator. BPC-only got me 60% of the way. Adding TB didn't finish the job — PRP did. Not selling PRP, just reporting what moved a tendon that had resisted 3 years of everything else. TB helped the global feel but didn't fix the specific tendon.

A
Joined 2026
21 posts
4/2/2026

Chronic Achilles, similar profile. TB addition on top of BPC gave me maybe 10% extra. Not worth the money for that alone. Heavy slow resistance loading for 12 weeks did more than the peptides at that stage.

T
Joined 2025
52 posts
4/3/2026

Noted. Probably pivoting to PRP consult + keeping rehab brutal. Peptides have given what they can for this one.

Pulley A2
  • BPC-157 · 250 mcg · 2x/day local · sub-Q
  • TB-500 · 2 mg · weekly · sub-Q
D
Joined 2025
122 posts
dr_doubtRegular
4/4/2026

Good call. When a tissue has been chronically abnormal for years, the 'repair' toolkit is limited. Doesn't mean nothing works — it means the things that work are structural (load, PRP, sometimes surgery), not primarily pharmacological.

R
Joined 2025
43 posts
5/3/2026

real question before you spend more money: did you actually establish a baseline of what the tendon looks like structurally before any of the BPC cycles? ultrasound or MRI showing the exact pathology at year 0? because if you didn't, you don't actually know if BPC moved the needle or if it just felt better while the tissue stayed the same. a lot of people think "i felt better" = "it worked" when really they just adapted to the pain or got stronger around the damage. if you've got imaging data showing progression then yeah, TB might be worth a shot, but if not you're basically guessing at what's actually changing in there.

Current
  • Tesamorelin · 1 mg · daily AM · sub-Q
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